Kucera J, Walro J M
Department of Neurology, School of Medicine, Boston University, MA 02118.
Neurosci Lett. 1988 Dec 19;95(1-3):88-92. doi: 10.1016/0304-3940(88)90637-4.
Immature muscle spindles were either deafferented or deefferented by selectively severing the sensory or motor nerve supply to the soleus muscle in neonatal rats. Experimental spindles were examined two months after the surgery using monoclonal antibodies specific for myosin heavy chains of slow-tonic and fast-twitch chicken muscles. The deefferented spindles exhibited a pattern of antibody binding that closely resembled that of normal adult intrafusal fibers, whereas deafferented intrafusal fibers were unreactive with the two antibodies. These observations suggest that sensory innervation is responsible for the expression of myosins in developing intrafusal muscle fibers of rat.
通过选择性切断新生大鼠比目鱼肌的感觉或运动神经供应，使未成熟的肌梭去传入或去传出。术后两个月，使用针对慢张力型和快肌型鸡肌肉肌球蛋白重链的单克隆抗体对实验性肌梭进行检查。去传出的肌梭呈现出一种抗体结合模式，与正常成年梭内肌纤维的模式非常相似，而去传入的梭内肌纤维对这两种抗体无反应。这些观察结果表明，感觉神经支配负责大鼠发育中梭内肌纤维中肌球蛋白的表达。
