Unidade de Laboratório de Análises Clínicas, Hospital das Clínicas, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
Departamento de Genética, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
J Med Virol. 2020 Dec;92(12):3219-3229. doi: 10.1002/jmv.25842. Epub 2020 Apr 28.
Information on human immunodeficiency virus (HIV) molecular epidemiology is required to verify HIV/AIDS (acquired immune deficiency syndrome) epidemic dynamics in different regions, as well as provide support for response to antiretroviral therapy, transmission of resistance mutations, disease progression, and viral spread. The aim of this study was to conduct a systematic review and meta-analysis of the frequency of HIV-1 subtypes in Northeast Brazil. Seventy-six articles that refer to HIV-1 and its subtypes in the Northeast Brazil and published between 1 January 1999 and 31 August 2019 were identified. We included 27 articles for the qualitative synthesis, thus analyzing results from 4466 patients and 4298 genomic sequences. The results showed that subtypes B, F, and C and recombinant BF were responsible for 76% (IC95%: 71-80), 8% (IC95%: 5-11), 2% (IC95%: 2-3), and 7% (IC95%: 4-12) infections, respectively. The highest proportion of subtype B infections (82.2%) was observed in Piauí, while the subtype F had a high frequency in Pernambuco (23.4%). Bahia presented 11.6% of the proportion of recombinant BF. In addition, several recombinants such as AG, BC, BCF, and BD have been identified in the region. This is the first systematic review and meta-analysis on the HIV-1 subtype distribution in Northeast Brazil and has shown a high circulating viral diversity. Although subtype B is predominant in Brazil, a large frequency of non-B subtypes has also been found, which may have consequences for response to antiretroviral therapy, disease progression, and transmission. Thus, HIV molecular epidemiological data are essential for epidemic prevention and control strategies.
需要了解人类免疫缺陷病毒 (HIV) 的分子流行病学信息，以验证不同地区的 HIV/AIDS（获得性免疫缺陷综合征）流行动态，并为抗逆转录病毒治疗反应、耐药突变传播、疾病进展和病毒传播提供支持。本研究旨在对巴西东北部的 HIV-1 亚型频率进行系统评价和荟萃分析。确定了 1999 年 1 月 1 日至 2019 年 8 月 31 日期间在巴西东北部涉及 HIV-1 及其亚型的 76 篇文章。我们纳入了 27 篇用于定性综合分析的文章，从而分析了来自 4466 名患者和 4298 个基因组序列的结果。结果显示，B、F 和 C 亚型以及 BF 重组亚型分别占 76%（95%CI：71-80）、8%（95%CI：5-11）、2%（95%CI：2-3）和 7%（95%CI：4-12）的感染。在皮奥伊州观察到 B 亚型感染的比例最高（82.2%），而在伯南布哥州 F 亚型的频率较高（23.4%）。巴伊亚州有 11.6%的 BF 重组比例。此外，该地区还发现了几种重组体，如 AG、BC、BCF 和 BD。这是巴西东北部 HIV-1 亚型分布的首次系统评价和荟萃分析，显示了高循环病毒多样性。尽管 B 亚型在巴西占主导地位，但也发现了大量非 B 亚型，这可能对抗逆转录病毒治疗反应、疾病进展和传播产生影响。因此，HIV 分子流行病学数据对于流行预防和控制策略至关重要。
