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美国五个州基于药房的美沙酮配药及前往美沙酮治疗机构的驾车时长:一项横断面研究。

Pharmacy-based methadone dispensing and drive time to methadone treatment in five states within the United States: A cross-sectional study.

作者信息

Joudrey Paul J, Chadi Nicholas, Roy Payel, Morford Kenneth L, Bach Paxton, Kimmel Simeon, Wang Emily A, Calcaterra Susan L

机构信息

Department of Internal Medicine, Yale School of Medicine, 367 Cedar Street, Harkness Hall A, New Haven, CT, 06520, USA.

Department of Pediatrics, Sainte-Justine University Hospital Centre, 3175 Chemin de la Cote Ste-Catherine, Montreal, QC, H3T 1C5, Canada.

出版信息

Drug Alcohol Depend. 2020 Mar 27;211:107968. doi: 10.1016/j.drugalcdep.2020.107968.

Abstract

BACKGROUND

Within the United States, there is a shortage of opioid treatment programs (OTPs), facilities which dispense methadone for opioid use disorder. It is unknown how pharmacy-based methadone dispensing, as available internationally, could affect methadone access. We aimed to compare drive times to the nearest OTP with drive times to the nearest chain pharmacy in urban and rural census tracts.

METHODS

Cross-sectional geospatial analysis of 2018 OTP location data and 2017 pharmacy location data. We included census tracts with non-zero population in Indiana, Kentucky, Ohio, Virginia, and West Virginia, states with highest rates of opioid overdose deaths. Our outcome was minimum drive time in minutes from census tract mean center of population to the nearest dispensing facility.

RESULTS

Among 7918 census tracts, median (IQR) drive time to OTPs increased from urban to increasingly rural census tract classification [16.1 min (10.2-25.9) to 48.4 min (34.0-63.3);p < .001]. Median (IQR) drive time to OTPs was greater than drive time to chain pharmacies among all census tracts: 19.6 min (11.6-35.1) versus 4.4 min (2.9-7.7) respectively; p < .001. The median (IQR) difference in drive time was greater for increasingly rural census tracts [11.5 min (6.1-19.2) to 35.2 min (19.6-49.7); p <.001] with pharmacy-based methadone dispensing.

CONCLUSION

Rural census tracts have disproportionately long drive times to OTPs. Drawing from policies to increase methadone access in countries like Canada and Australia, this geographic methadone disparity could be mitigated through implementation of pharmacy-based methadone dispensing.

摘要

背景

在美国,阿片类药物治疗项目(OTP)短缺,OTP是指为阿片类药物使用障碍患者发放美沙酮的机构。国际上现有的基于药房的美沙酮发放模式会如何影响美沙酮的可及性尚不清楚。我们旨在比较城市和农村普查区到最近的OTP的驾车时间与到最近的连锁药店的驾车时间。

方法

对2018年OTP位置数据和2017年药房位置数据进行横断面地理空间分析。我们纳入了印第安纳州、肯塔基州、俄亥俄州、弗吉尼亚州和西弗吉尼亚州人口非零的普查区,这些州的阿片类药物过量死亡发生率最高。我们的结果是从普查区人口平均中心到最近发放机构的最短驾车时间(以分钟计)。

结果

在7918个普查区中,从城市到农村程度不断增加的普查区分级,到OTP的驾车时间中位数(四分位间距)逐渐增加[16.1分钟(10.2 - 25.9)至48.4分钟(34.0 - 63.3);p <.001]。在所有普查区中,到OTP的驾车时间中位数(四分位间距)大于到连锁药店的驾车时间:分别为19.6分钟(11.6 - 35.1)和4.4分钟(2.9 - 7.7);p <.001。对于基于药房发放美沙酮的农村程度不断增加的普查区,驾车时间的中位数(四分位间距)差异更大[11.5分钟(6.1 - 19.2)至35.2分钟(19.6 - 49.7);p <.001]。

结论

农村普查区到OTP的驾车时间长得不成比例。借鉴加拿大和澳大利亚等国增加美沙酮可及性的政策,通过实施基于药房的美沙酮发放可缓解这种地理上的美沙酮差异。

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