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阿片类药物治疗项目中用于阿片类物质使用障碍的药物供应情况。

Availability of Medications for Opioid Use Disorder in Opioid Treatment Programs.

作者信息

Lindenfeld Zoe, Cantor Jonathan H, Mauri Amanda I, Bandara Sachini, Suryavanshi Aarya, Krawczyk Noa

机构信息

Edward J. Bloustein School of Planning and Public Policy, Rutgers University, New Brunswick, New Jersey.

RAND, Santa Monica, California.

出版信息

JAMA Netw Open. 2025 Jun 2;8(6):e2517616. doi: 10.1001/jamanetworkopen.2025.17616.

Abstract

IMPORTANCE

As the primary facilities authorized to dispense methadone, opioid treatment programs (OTPs) are a critical access point for medications for opioid use disorder (MOUD). However, research is limited on the extent to which OTPs offer a broad range of MOUD and on the characteristics of programs that provide more comprehensive medication offerings.

OBJECTIVE

To assess the percentage of US OTPs offering all 3 forms of MOUD (methadone, buprenorphine, and naltrexone) and compare organizational and county characteristics of OTPs with different MOUD service offerings.

DESIGN, SETTING, AND PARTICIPANTS: This longitudinal cross-sectional study used data on a panel of OTPs listed in the annual National Directory of Drug and Alcohol Use Treatment Facilities from 2017 to 2023.

MAIN OUTCOMES AND MEASURES

Measures included the percentage of OTPs offering buprenorphine, extended-release naltrexone, or all 3 MOUD from 2017 to 2023 (assuming all OTPs offered methadone). Descriptive statistics on organizational and county characteristics of OTPs by MOUD offerings were collected. Three longitudinal logistic regression models were used to estimate the odds of different MOUD offerings within OTPs, adjusting for organizational and county-level characteristics.

RESULTS

This analysis included 10 298 facility-year observations, ranging from 1211 in 2017 to 1421 in 2023. From 2017 to 2023, the percentage of OTPs offering MOUD beyond methadone increased (buprenorphine: 811 [67.0%] in 2017 to 1209 [85.1%] in 2023; naltrexone: 463 [38.2%] in 2017 to 749 [52.7%] in 2023; all 3 MOUD: 402 [33.2%] in 2017 to 639 [45.0%] in 2023). OTPs offering all 3 MOUD (3985 [38.7%]) had significantly higher odds of accepting Medicare (adjusted odds ratio [AOR], 2.14; 95% CI, 1.67-2.74); offering peer services (AOR, 1.63; 95% CI, 1.25-2.12), mental health services (AOR, 2.07; 95% CI, 1.53-2.80), and telemedicine services (AOR, 1.53; 95% CI, 1.22-1.92); and being private nonprofit (AOR, 7.45; 95% CI, 4.67-11.87) or government operated (AOR, 41.83; 95% CI, 19.71-88.75) compared with private for profit.

CONCLUSIONS

In this cross-sectional study of OTPs, although the availability of MOUD beyond methadone increased over time, most OTPs still did not offer all 3 forms of MOUD as of 2023. Specific organizational characteristics, such as being government operated and accepting Medicare, were associated with more comprehensive MOUD offerings. Future research should evaluate why OTPs vary in their MOUD offerings.

摘要

重要性

作为被授权配发美沙酮的主要机构,阿片类药物治疗项目(OTP)是阿片类药物使用障碍(MOUD)药物的关键获取点。然而,关于OTP提供多种MOUD的程度以及提供更全面药物治疗方案的项目特征的研究有限。

目的

评估提供所有三种MOUD形式(美沙酮、丁丙诺啡和纳曲酮)的美国OTP的百分比,并比较提供不同MOUD服务的OTP的组织和县级特征。

设计、设置和参与者:这项纵向横断面研究使用了2017年至2023年年度《国家药物和酒精使用治疗设施目录》中列出的一组OTP的数据。

主要结果和指标

指标包括2017年至2023年提供丁丙诺啡、长效纳曲酮或所有三种MOUD的OTP的百分比(假设所有OTP都提供美沙酮)。收集了按MOUD提供情况划分的OTP的组织和县级特征的描述性统计数据。使用三个纵向逻辑回归模型来估计OTP内不同MOUD提供情况的几率,并对组织和县级特征进行调整。

结果

该分析包括10298个机构年度观察数据,范围从2017年的1211个到2023年的1421个。从2017年到2023年,提供除美沙酮之外的MOUD的OTP的百分比有所增加(丁丙诺啡:2017年为811个[67.0%],2023年为1209个[85.1%];纳曲酮:2017年为463个[38.2%],2023年为749个[52.7%];所有三种MOUD:2017年为402个[33.2%],2023年为639个[

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