Sun W W, Zhang L, Gu M M, Zhang Y Q, Qiu C M, Da Q
Department of Pathology, Shanghai Songjiang District Central Hospital, Shanghai 201600, China.
Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
Zhonghua Bing Li Xue Za Zhi. 2020 Apr 8;49(4):343-347. doi: 10.3760/cma.j.cn112151-20190720-00404.
To investigate the clinicopathological characteristics of gastric adenocarcinoma of the fundic gland(GA-FG). A total of 6 patients with GA-FG admitted from January 2014 to May 2019 were identified at Shanghai Songjiang District Central Hospital.Analyzed endoscopic findings, pathological characteristics and immunohistochemical staining of the lesions and reviewed relevant literatures. Among the 6 patients, 3 were male, 3 were female, and the mean age was 66 years. The most common clinical presentation was epigastric discomfort. Gastroscopic examination revealed an elevated or flat lesion in the body of the stomach, with a diameter of 0.4 to 1.0 cm. Histopathologically, they mainly composed of main cells, but there were also scattered parietal cells, arranged in an irregular tubular or cord-like structure, and formed anastomosis branches. The tumor cells were immunohistochemically positive for MUC6 and pepsinogen 1. GA-FG is a rare variant of well-differentiated adenocarcinoma. It is important to understand its clinical features and histological morphology for more accurate diagnosis.
探讨胃底腺型胃癌（GA-FG）的临床病理特征。对上海市松江区中心医院2014年1月至2019年5月收治的6例GA-FG患者进行研究。分析病变的内镜检查结果、病理特征及免疫组化染色情况，并复习相关文献。6例患者中，男性3例，女性3例，平均年龄66岁。最常见的临床表现为上腹部不适。胃镜检查显示胃体部有隆起或扁平病变，直径0.4至1.0厘米。组织病理学上，主要由主细胞组成，但也有散在的壁细胞，呈不规则管状或条索状结构，并形成吻合分支。肿瘤细胞免疫组化MUC6和胃蛋白酶原1呈阳性。GA-FG是一种罕见的高分化腺癌变异型。了解其临床特征和组织形态学对于更准确的诊断很重要。
