Genetic analysis of fundic gland‑type gastric adenocarcinoma.

This study aimed to analyze the molecular characteristics of gastric adenocarcinoma of the fundic-gland type (GAFG) and explore the possible mechanism of tumor development. Samples from 10 Chinese patients with GAFG were collected at the Peking University International Hospital and Liaocheng People's Hospital between January 2015 and March 2022. The nucleic acid sequence of Epstein Barr virus-encoded RNA (EBV-EBER) was detected by hybridization. Genetic mutation information for , , , , , , , , , , , , and was obtained by Next-Generation Sequencing, and the relevant literature was reviewed. A total of eight instances of missense mutations were detected, consisting of seven cases with mutations, two cases with mutations, and one case with a mutation. Additionally, two patients had simultaneous missense mutations in and . Nonsynonymous mutations in , , , , , , , , , or were not observed in any cases. In addition, all tumors were EBER-negative. GAFG exhibits diversity at the molecular level, and mutations are more common than mutations, mutations, and microsatellite instability. To date, no association between EBV/ and GAFG has been found.