College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Auris Nasus Larynx. 2020 Aug;47(4):580-586. doi: 10.1016/j.anl.2020.01.005. Epub 2020 Apr 5.
Due to its rarity and similar sound, typewriter tinnitus (TT) can be misdiagnosed as middle ear myoclonic tinnitus (MEMT). We aim to clarify the characteristics of TT compared to MEMT, and the long-term therapeutic response to carbamazepine.
Fourteen patients with TT and 28 patients with MEMT were enrolled.
TT patients were older than MEMT patients, and their tinnitus symptoms were mostly unilateral. Tinnitus symptoms, which is associated with dizziness, facial spasm, and head motion, were more common in TT, whereas MEMT were more related to noise. Acoustic reflex decay perturbation and low loudness discomfort level were diagnostic signs in MEMT patients, while decreased level of wave II in ABR was the most reliable sign in TT patients. All TT patients exhibited partial or complete response to carbamazepine, but there was a relapse rate after withdrawal of the drug was 60%. Increase in age and longer duration of symptoms were the risk factors of relapse of TT.
The different characteristics observed in this study will be helpful to diagnose TT and MENT. Duration of tinnitus was the most important long-term prognostic factor of the carbamazepine trial, which indicates the importance of its earlier diagnosis.
由于其罕见性和相似的声音,打字机性耳鸣(TT)可能被误诊为中耳肌阵挛性耳鸣(MEMT)。我们旨在阐明 TT 与 MEMT 的特征,以及卡马西平的长期治疗反应。
纳入 14 例 TT 患者和 28 例 MEMT 患者。
TT 患者比 MEMT 患者年龄更大,且其耳鸣症状多为单侧。与头晕、面部痉挛和头部运动相关的耳鸣症状在 TT 中更为常见,而 MEMT 则与噪声更为相关。声反射衰减干扰和低响度不适水平是 MEMT 患者的诊断标志,而 ABR 中 II 波幅度降低则是 TT 患者最可靠的标志。所有 TT 患者对卡马西平均表现出部分或完全反应,但停药后复发率为 60%。年龄增加和症状持续时间延长是 TT 复发的危险因素。
本研究观察到的不同特征将有助于诊断 TT 和 MENT。耳鸣持续时间是卡马西平试验最重要的长期预后因素,这表明早期诊断的重要性。