（丁硫基）羰基：寡核糖核苷酸合成中鸟嘌呤和尿嘧啶残基的新型保护基团。
(Butylthio)carbonyl group: a new protecting group for the guanine and uracil residues in oligoribonucleotide synthesis.
作者信息
Yamakage S, Fujii M, Horinouchi Y, Takaku H
机构信息
Department of Industrial Chemistry, Chiba Institute of Technology, Japan.
出版信息
Nucleic Acids Symp Ser. 1988(19):9-12.
PMID:3226925
Abstract
The protection of the O6-amide and N2-amino groups of guanosine and the N3-imide group of uridine with the (butylthio)carbonyl group is described. This group could be rapidly introduced in good yields and removed very easily under the conventional deprotective conditions of the exo-amino acyl groups of other nucleoside bases.
摘要
描述了用（丁硫基）羰基对鸟苷的O6-酰胺基和N2-氨基以及尿苷的N3-酰亚胺基进行保护。该基团能够以良好的产率快速引入，并且在其他核苷碱基的外氨基酰基的常规脱保护条件下很容易除去。
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