Department of Otolaryngology, Head and Neck Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang, China.
Department of Otolaryngology, Head and Neck Surgery, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden.
Sci Rep. 2020 Apr 8;10(1):6057. doi: 10.1038/s41598-020-63046-z.
Idiopathic sudden sensorineural hearing loss (ISSNHL) is an emergency disease requiring immediate diagnosis and treatment. The incidence of ISSNHL in the Western countries' population was estimated to 5-20 per 100,000 inhabitants. The etiology of ISSNHL remains unknown. Its pathogenesis is most often suggested to be due to a disturbed microcirculation and infection. Previous studies have reported that comorbidities, including hypertension, diabetes mellitus (DM), and hyperfibrinogenemia are risk factors of ISSNHL. This study aimed at investigating the clinical characteristics, laboratory parameters and comorbidities of patients with ISSNHL. Our study suggests that the annual incidence of ISSNHL in China mainland is 19 per 100 000. The clinical characteristics and prevalence of comorbidities of ISSNHL patients are different according to age distribution and hearing results. Moreover, the patients with vertigo, hypertension, DM and high TG suffered more often from severe hearing loss compared with the counterparts. This indicates that the cardiovascular and metabolic diseases (hypertension and hyperlipidemia) appeared to be closely associated with the occurrence and severity of ISSNHL.
特发性突发性聋（ISSNHL）是一种需要立即诊断和治疗的急症。据估计，西方国家人群中 ISSNHL 的发病率为每 10 万人中有 5-20 人。 ISSNHL 的病因仍然未知。其发病机制通常被认为是由于微循环紊乱和感染引起的。先前的研究报告称，高血压、糖尿病（DM）和高纤维蛋白原血症等合并症是 ISSNHL 的危险因素。本研究旨在探讨 ISSNHL 患者的临床特征、实验室参数和合并症。我们的研究表明，中国大陆 ISSNHL 的年发病率为每 10 万人中有 19 人。根据年龄分布和听力结果， ISSNHL 患者的临床特征和合并症的患病率不同。此外，与对照组相比，有眩晕、高血压、DM 和高 TG 的患者更常患有严重听力损失。这表明心血管和代谢疾病（高血压和高脂血症）似乎与 ISSNHL 的发生和严重程度密切相关。
