Medical School of Hubei MinZu University, Enshi, 445000, Hubei, People's Republic of China.
Demonstration Center for Experimental Basic Medicine Education of Wuhan University, Wuhan, 430071, Hubei, People's Republic of China.
Med Oncol. 2020 Apr 8;37(5):44. doi: 10.1007/s12032-020-01369-7.
Trillin is a constituent of total Trillium Tschonoskii Maxim (TTM), which is extracted from TTM and displayed anti-tumor effect in many tumor cell lines. However, the anti-tumor mechanism of trillin is still unclear. This study demonstrated that trillin could dramatically inhibit hepatoma carcinoma cell proliferation, induce apoptosis and decrease migration and invasion through suppressing phosphorylated STAT3 translocated to nucleus. Trillin could down-regulate Bcl-2 and Survivin, up-regulate cleaved PRAP, leading to dramatically apoptosis; trillin could also down-regulate MMP1, MMP2, MucI and VEGF, which displayed an inhibition effect on hepatocellular tumor cells invasion and development. The results of this study indicated the potential utility of trillin as a STAT3 inhibitor for the treatment of cancers.
鬼臼毒素是总重楼皂苷 Tschonoskii 马克西米（TTM）的成分之一，从 TTM 中提取出来，并在许多肿瘤细胞系中显示出抗肿瘤作用。然而，鬼臼毒素的抗肿瘤机制尚不清楚。本研究表明，鬼臼毒素可通过抑制磷酸化 STAT3 转位入核，显著抑制肝癌细胞增殖，诱导细胞凋亡，并减少迁移和侵袭。鬼臼毒素可以下调 Bcl-2 和 Survivin，上调 cleaved PRAP，从而显著促进细胞凋亡；鬼臼毒素还可以下调 MMP1、MMP2、MucI 和 VEGF，对肝癌细胞的侵袭和发展有抑制作用。本研究结果表明，鬼臼毒素作为 STAT3 抑制剂在癌症治疗中有一定的应用潜力。
