Department of Obstetrics and Gynecology, University of Health Sciences Istanbul, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, 34180, Istanbul, Turkey.
Institute of Child Health, Istanbul University, Faculty of Medicine, 34200, Istanbul, Turkey.
Arch Gynecol Obstet. 2020 Jun;301(6):1553-1560. doi: 10.1007/s00404-020-05520-7. Epub 2020 Apr 8.
Our aim was to investigate the serum endocan levels and carotid artery intima-media thickness (CIMT) measurements of pre- and postmenopausal patients to clarify the relationship between the menopausal transition and endothelial injury.
This cross-sectional study was conducted on women who were premenopausal and postmenopausal between January 2019 and June 2019. The patients were divided into two groups according to premenopausal (n = 32) and postmenopausal (n = 32) status. Serum endocan levels were assessed by enzyme-linked immunosorbent assay (ELISA). CIMT ultrasonographic measurements were determined. Hormonal and biochemical parameters were measured. The validated Menopause Rating Scale (MRS) questionnaire was used on all women.
Serum endocan levels were significantly higher in the postmenopausal group than in the premenopausal group (222.90 ± 121.00 ng/L and 146.62 ± 41.88 ng/L, p = 0.033, respectively). The mean CIMT was significantly higher in the postmenopausal group than in the premenopausal cohort (0.70 ± 0.14 mm and 0.58 ± 0.11 mm, p < 0.001, respectively). A positive correlation was found between body mass index (BMI), systolic blood pressure (SBP), abdominal circumference (AC), and CIMT and postmenopausal serum endocan levels. Serum endocan levels with a cutoff point of 141.14 ng/L identified women with significant CIMT levels with sensitivity of 73.8% and specificity of 77.3%. A positive correlation was found between CIMT and endocan and total MRS scores.
Serum endocan levels were associated with CIMT during the menopausal transition period. Increased circulating endocan levels can be a predictor of cardiovascular risk in pre- and postmenopausal women.
本研究旨在探讨绝经前后患者的血清内皮细胞(endocan)水平和颈动脉内膜-中层厚度(CIMT)，以阐明绝经过渡期与内皮损伤之间的关系。
本横断面研究纳入了 2019 年 1 月至 6 月期间处于绝经前和绝经后的女性患者。根据绝经前（n=32）和绝经后（n=32）状态将患者分为两组。采用酶联免疫吸附试验（ELISA）检测血清 endocan 水平。行 CIMT 超声测量。测定激素和生化参数。所有女性均使用经过验证的绝经评分量表（MRS）问卷。
绝经后组的血清 endocan 水平明显高于绝经前组（222.90±121.00 ng/L和 146.62±41.88 ng/L，p=0.033）。绝经后组的平均 CIMT 明显高于绝经前组（0.70±0.14 mm 和 0.58±0.11 mm，p<0.001）。BMI、收缩压（SBP）、腹围（AC）与 CIMT 和绝经后血清 endocan 水平呈正相关。血清 endocan 水平截断值为 141.14 ng/L 时，可识别出 CIMT 水平显著升高的女性，其敏感性为 73.8%，特异性为 77.3%。CIMT 与 endocan 和总 MRS 评分呈正相关。
血清 endocan 水平与绝经过渡期的 CIMT 相关。循环 endocan 水平升高可预测绝经前和绝经后女性的心血管风险。
