Altintas Nejat, Mutlu Levent Cem, Akkoyun Dursun Cayan, Aydin Murat, Bilir Bulent, Yilmaz Ahsen, Malhotra Atul
Department of Pulmonary, Sleep and Critical Care Medicine, School of Medicine, Namik Kemal University, Tekirdag, Turkey
Department of Pulmonary, Sleep and Critical Care Medicine, School of Medicine, Namik Kemal University, Tekirdag, Turkey.
Angiology. 2016 Apr;67(4):364-74. doi: 10.1177/0003319715590558. Epub 2015 Jun 15.
Obstructive sleep apnea (OSA) is associated with increased cardiovascular (CV) morbidity and mortality. Endocan is a surrogate endothelial dysfunction marker that may be associated with CV risk factors. In this study, we tested whether serum endocan is a biomarker for OSA. Serum endocan levels were measured at baseline in 40 patients with OSA and 40 healthy controls and after 3 months of continuous positive airway pressure (CPAP) treatment in the patients with OSA. All participants were evaluated by full polysomnography. Flow-mediated dilatation (FMD) and carotid intima media thickness (cIMT) were measured in all participants. Endocan levels were significantly higher in patients with OSA than in healthy controls. After adjusting confounders, endocan was a good predictor of OSA. Endocan levels correlated with OSA severity (measured by the apnea-hypopnea index [AHI]). After 3 months of CPAP treatment, endocan levels significantly decreased. Endocan levels were significantly and independently correlated with cIMT and FMD after multiple adjustments. The cIMT and FMD also had significant and independent correlation with AHI. Endocan might be a useful marker for the predisposition of patients with OSA to premature vascular disease.
阻塞性睡眠呼吸暂停（OSA）与心血管（CV）发病率和死亡率增加相关。内脂素是一种替代内皮功能障碍标志物，可能与心血管危险因素有关。在本研究中，我们测试了血清内脂素是否为OSA的生物标志物。在40例OSA患者和40例健康对照者的基线时测量血清内脂素水平，并在OSA患者接受持续气道正压通气（CPAP）治疗3个月后再次测量。所有参与者均通过全夜多导睡眠图进行评估。在所有参与者中测量血流介导的血管舒张（FMD）和颈动脉内膜中层厚度（cIMT）。OSA患者的内脂素水平显著高于健康对照者。在调整混杂因素后，内脂素是OSA的良好预测指标。内脂素水平与OSA严重程度（通过呼吸暂停低通气指数[AHI]衡量）相关。CPAP治疗3个月后，内脂素水平显著下降。经过多次调整后，内脂素水平与cIMT和FMD显著且独立相关。cIMT和FMD也与AHI显著且独立相关。内脂素可能是OSA患者易患早发性血管疾病的有用标志物。
