Opposite effects of restraint on morphine analgesia and naloxone-induced jumping.

It has been demonstrated that the effects of exogenous opiates like morphine could be modified by exposure of an organism to stress, but it is uncertain whether this modification is due to the action of endogenous opioid peptides released by stressful stimuli. The stress of restraint produced an antinociceptive response in mice measured by a latency to escape from a hot plate and, in addition, markedly potentiated analgesia induced by low doses of morphine. Both effects were antagonized by naloxone in a dose-dependent manner. On the other hand, restraint reduced the naloxone-precipitated jumping after single morphine injection. Morphine analgesia and a jumping response were not correlated when tested in two different strains of mice. It is suggested that the enhancement of morphine analgesia by restraint and the reduction in naloxone-induced jumping are mediated via independent mechanisms.