Department of Pathology, School of Veterinary Medicine and Animal Sciences, Research Centre for Veterinary Toxicology (CEPTOX), University of São Paulo, Pirassununga, SP, Brazil.
Laboratório Federal de Defesa Agropecuária (LFDA-RS), Ministério da Agricultura, Pecuária e Abastecimento, Porto Alegre, RS, Brazil.
J Vet Pharmacol Ther. 2020 Sep;43(5):477-484. doi: 10.1111/jvp.12862. Epub 2020 Apr 8.
Ivermectin (IVM) is one of the most widely used antiparasitic drugs worldwide and has become the drug of choice for anthelmintic and tick treatment in beef cattle production. It is known that pharmacokinetic parameters are fundamental to the rational use of a drug and food safety and these parameters are influenced by different factors. The aim of this study was to evaluate the pharmacokinetic profile of IVM in Bos indicus, Bos taurus, and crossbreed cattle (B. indicus × B. taurus) kept under same field conditions and the possible impacts of sex and IVM formulation (1% and 3.15%). It was observed that IVM concentration was significantly affected by breed. The plasma concentrations of IVM, AUC, C , and t were significantly higher in B. indicus compared to B. taurus. Crossbreed animals showed an intermediate profile between European and Indian cattle. No alteration in pharmacokinetics parameters was detected when comparing different gender. Concerning the pharmacokinetic data of IVM formulation, it was verified that T , AUC, and t were higher in 3.15% IVM animals than those from 1% IVM formulation. The results clearly indicated that the IVM plasma concentrations in B. indicus were higher than that in B. taurus.
伊维菌素（IVM）是全球应用最广泛的驱虫药之一，已成为肉牛生产中驱虫和蜱治疗的首选药物。众所周知，药代动力学参数是合理使用药物和食品安全的基础，这些参数受到不同因素的影响。本研究旨在评估在相同田间条件下饲养的印度野牛、欧洲牛和杂交牛（印度野牛×欧洲牛）的伊维菌素药代动力学特征，以及性别和伊维菌素制剂（1%和 3.15%）可能产生的影响。结果表明，伊维菌素的浓度受品种影响显著。与欧洲牛相比，印度野牛的伊维菌素血浆浓度、AUC、C 和 t 显著更高。杂交牛的药代动力学特征介于欧洲牛和印度牛之间。不同性别之间未检测到药代动力学参数的改变。关于伊维菌素制剂的药代动力学数据，3.15%伊维菌素组的 T 、AUC 和 t 均高于 1%伊维菌素组。结果清楚地表明，印度野牛的伊维菌素血浆浓度高于欧洲牛。
