Grimmer Timo, Laub Theresa, Hapfelmeier Alexander, Eisele Tamara, Fatke Bastian, Hölzle Patricia, Lüscher Sandra, Parchmann Anna-Mareike, Rentrop Michael, Schwerthöffer Dirk, Müller-Sarnowski Felix, Ortner Marion, Goldhardt Oliver, Kurz Alexander, Förstl Hans, Alexopoulos Panagiotis
Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technical University of Munich, School of Medicine, Munich, Germany.
Institute of Medical Statistics and Epidemiology, Klinikum rechts der Isar, Technical University of Munich, School of Medicine, Munich, Germany.
Alzheimers Dement. 2020 May;16(5):759-769. doi: 10.1002/alz.12072. Epub 2020 Apr 8.
In mice there might be an association between sleep deprivation and amyloid β plasma levels. Hence, we examined whether amyloid plasma levels are associated with sleep duration or fragmentation in 17 psychiatrists on-call.
Amyloid β (Aβ)42, Aβ40, and soluble amyloid precursor protein β (sAPP-β) plasma concentrations were measured at the beginning and end of 90 on-call nights, and analyzed using generalized linear models.
In on-call nights, a 10.7% reduction of Aβ42 was revealed overnight. Every single short sleep interruption diminished this reduction by 5.4%, as well as every pg/mL of sAPP-β by 1.2%, each copy of APOE ε4 by 10.6%, and each year of professional experience by 3.0%.
The extent of sleep fragmentation diminishes the physiological overnight reduction of Aβ42 but not Aβ40 plasma levels in the same direction as the enzyme for Aβ42 production, the genetic risk factor for Alzheimer's disease (AD), and on-call experience. Might on-call duty and sleep fragmentation in general alter the risk for AD?
在小鼠中，睡眠剥夺与血浆β淀粉样蛋白水平之间可能存在关联。因此，我们研究了17名值班精神科医生的血浆淀粉样蛋白水平是否与睡眠时间或睡眠片段化有关。
在90个值班夜晚的开始和结束时测量血浆β淀粉样蛋白（Aβ）42、Aβ40和可溶性淀粉样前体蛋白β（sAPP-β）的浓度，并使用广义线性模型进行分析。
在值班夜晚，Aβ42在夜间减少了10.7%。每一次短暂的睡眠中断使这种减少降低5.4%，每pg/mL的sAPP-β降低1.2%，每一份APOE ε4降低10.6%，每一年的专业经验降低3.0%。
睡眠片段化的程度会削弱Aβ42在夜间的生理性减少，但不会削弱Aβ40的血浆水平，其削弱方向与Aβ42产生的酶、阿尔茨海默病（AD）的遗传风险因素以及值班经验相同。一般来说，值班任务和睡眠片段化会改变患AD的风险吗？
