Liu Yajing, Chen Lushi, Huang Shuyun, Zhang Chengguo, Lv Zeping, Luo Jiali, Shang Pan, Wang Yukai, Xie Haiqun
Department of Neurology, First People's Hospital of Foshan, Foshan, China.
National Research Center for Rehabilitation Technical Aids, Rehabilitation Hospital, Beijing, China.
Front Neurosci. 2020 Dec 21;14:611432. doi: 10.3389/fnins.2020.611432. eCollection 2020.
To investigate the extent to which sleep quality associated with plasma Aβ levels in amnestic mild cognitive impairment (aMCI) elderly.
A total of 172 cognitively normal (NC) elderly and 133 aMCI elderly were included in this study. For the evaluation of sleep quality, the Pittsburgh Sleep Quality Index (PSQI) was used. Levels of plasma Aβ were determined by the sandwich enzyme-linked immunosorbent assay technique. Multivariable linear regression analysis was applied to evaluate associations between sleep quality and plasma Aβ levels after adjusting potential confounders.
Compared to NC subjects, participants with aMCI had a higher global PSQI score (8.72 ± 3.87 vs. 7.10 ± 3.07, < 0.001). The global PSQI score was positively associated with plasma Aβ level in the aMCI group (β = 0.063, 95% CI 0.001-0.125, and = 0.049) but not in the NC group ( > 0.05). Additionally, a higher global PSQI score was associated with a higher plasma Aβ/Aβ ratio in both NC (β = 0.010, 95% CI 0.003-0.016, and = 0.003) and aMCI groups (β = 0.012, 95% CI 0.005-0.018, and < 0.001). The association between global PSQI score and plasma Aβ/Aβ ratio was stronger in individuals with aMCI relative to the NC subjects (β = 0.076 vs. 0.030, for interaction = 0.023).
Poor sleep quality was associated with plasma Aβ and Aβ/Aβ ratio, with a stronger effect among individuals with aMCI. A better understanding of the role of sleep in plasma Aβ levels in aMCI patients could lead to effective sleep-based intervention against the risk of Alzheimer's disease.
探讨遗忘型轻度认知障碍（aMCI）老年人的睡眠质量与血浆β淀粉样蛋白（Aβ）水平的关联程度。
本研究共纳入172名认知正常（NC）老年人和133名aMCI老年人。采用匹兹堡睡眠质量指数（PSQI）评估睡眠质量。采用夹心酶联免疫吸附测定技术测定血浆Aβ水平。应用多变量线性回归分析，在调整潜在混杂因素后评估睡眠质量与血浆Aβ水平之间的关联。
与NC受试者相比，aMCI参与者的PSQI总分更高（8.72±3.87 vs. 7.10±3.07，P<0.001）。在aMCI组中，PSQI总分与血浆Aβ水平呈正相关（β=0.063，95%CI 0.001-0.125，P=0.049），而在NC组中无相关性（P>0.05）。此外，在NC组（β=0.010，95%CI 0.003-0.016，P=0.003）和aMCI组（β=0.012，95%CI 0.005-0.018，P<0.001）中，较高的PSQI总分均与较高的血浆Aβ/Aβ42比值相关。与NC受试者相比，aMCI个体的PSQI总分与血浆Aβ/Aβ42比值之间的关联更强（β=0.076 vs. 0.030，交互作用P=0.023）。
睡眠质量差与血浆Aβ及Aβ/Aβ42比值相关，在aMCI个体中影响更强。更好地理解睡眠在aMCI患者血浆Aβ水平中的作用，可能会带来基于睡眠的有效干预措施，以降低患阿尔茨海默病的风险。
