Department of Urology, The third affiliated hospital of Southern Medical University, Guangzhou, Guangdong 510630, P.R. China.
Department of Stomatology, The twelfth People's Hospital of Guangzhou, Guangzhou, Guangdong 528000, P.R. China.
Int Braz J Urol. 2021 Jan-Feb;47(1):8-19. doi: 10.1590/S1677-5538.IBJU.2019.0210.
Recently, several studies have found that obesity had a protective effect against varicocele, but no meta-analysis has confirmed this finding. Therefore, we conducted this meta-analysis to investigate the association between body mass index (BMI) and varicocele.
We searched for studies in PubMed, Science Direct and the Cochrane Library from inception until February 2018. The association between BMI and varicocele was assessed by pooling the odds ratios (ORs).
Eleven eligible studies with a total study population of 1.376.658 participants were included in our analysis. According to BMI, the subjects were defined as belonging to the obese, overweight and underweight groups. Our results showed that the obese group had a lower risk of varicocele when compared with the normal weight group (odds ratio [OR] 0.46, 95% confidence intervals [CIs] 0.37-0.58). Additionally, an overweight BMI had a protective effect against varicocele (OR 0.70, 95% CIs, 0.56-0.86). However, underweight patients had a more than 30% higher risk of varicocele (OR 1.31, 95% CI, 1.04-1.64). Furthermore, there was no publication bias in any of the analyses.
Our study demonstrates that BMI is negatively associated with the presence of varicocele.
最近有几项研究发现肥胖对精索静脉曲张具有保护作用，但尚无荟萃分析证实这一发现。因此，我们进行了这项荟萃分析，以调查体重指数（BMI）与精索静脉曲张之间的关系。
我们在 PubMed、Science Direct 和 Cochrane Library 中检索了从创建到 2018 年 2 月的研究。通过汇总比值比（ORs）来评估 BMI 与精索静脉曲张之间的关联。
我们的分析共纳入了 11 项符合条件的研究，总计 1376658 名研究对象。根据 BMI，将受试者定义为肥胖、超重和体重不足组。我们的结果表明，与正常体重组相比，肥胖组精索静脉曲张的风险较低（比值比 [OR] 0.46，95%置信区间 [CI] 0.37-0.58）。此外，超重 BMI 对精索静脉曲张具有保护作用（OR 0.70，95%CI，0.56-0.86）。然而，体重不足的患者精索静脉曲张的风险增加了 30%以上（OR 1.31，95%CI，1.04-1.64）。此外，任何分析均不存在发表偏倚。
我们的研究表明 BMI 与精索静脉曲张的发生呈负相关。
