体尺参数对精索静脉曲张患病率和严重程度的影响：系统评价和荟萃分析。

Effect of somatometric parameters on the prevalence and severity of varicocele: a systematic review and meta-analysis.

机构信息

The Neonatal Screening Center in Henan Province, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

Henan Human Sperm Bank, The Third Affiliated Hospital of Zhengzhou University, No.7 Front Kangfu Street, Er'qi District, Zhengzhou, 450052, People's Republic of China.

出版信息

Reprod Biol Endocrinol. 2021 Jan 20;19(1):11. doi: 10.1186/s12958-021-00695-3.

DOI:10.1186/s12958-021-00695-3

PMID:33472653

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7816346/

Abstract

BACKGROUND

Published studies have shown contradictory results regarding the relationship between somatometric parameters and varicoceles. We performed a systematic review and meta-analysis to investigate the possible effects of age, height, weight, and body mass index (BMI) on the presence and severity of varicoceles.

METHODS

Databases including EMBASE, MEDLINE, PubMed, Cochrane Library, China National Knowledge Infrastructure (CNKI), Web of Science, and Google Scholar were systematically searched to identify relevant articles published up to March 2020. Two researchers independently identified eligible articles and extracted data. Cochran's Q statistic and I statistics were used to assess heterogeneity. Meta-analysis was performed using StataSE 12.0 software (StataCorp LP, USA). Random-effects models were used to obtain the weighted mean differences (WMDs) and 95% confidence intervals (CIs). Publication bias was assessed using Begg's funnel plot and Egger's regression test.

RESULTS

The search strategy produced 272 articles, of which 18 articles were eligible according to the inclusion/exclusion criteria. A total of 56,325 patients with varicocele and 1,334,694 patients without varicocele were included in the meta-analysis to evaluate the effect of somatometric parameters on the presence and severity of varicocele. The overall results demonstrated that the presence of varicoceles was significantly associated with height (WMD = 1.41, 95% CI = 1.07 to 1.74, P < 0.001) and inversely correlated with BMI (WMD = - 1.35, 95% CI = -1.67 to - 1.03, P < 0.001) but not with age (WMD = -0.93, 95% CI = -2.19 to 0.33, P = 0.149) or weight (WMD = 0.24, 95% CI = -2.24 to 2.72, P = 0.850). The severity of varicocele was inversely correlated with increased BMI but not with age.

CONCLUSION

The presence of varicoceles was significantly associated with height and inversely correlated with BMI.

摘要

背景

已发表的研究结果表明，体尺参数与精索静脉曲张之间的关系存在矛盾。我们进行了一项系统评价和荟萃分析，以研究年龄、身高、体重和体重指数（BMI）对精索静脉曲张的存在和严重程度的可能影响。

方法

系统检索了 EMBASE、MEDLINE、PubMed、Cochrane 图书馆、中国知网（CNKI）、Web of Science 和 Google Scholar 等数据库，以确定截至 2020 年 3 月发表的相关文章。两位研究人员独立确定了合格的文章并提取了数据。使用 Cochran's Q 统计量和 I 统计量评估异质性。使用 StataSE 12.0 软件（StataCorp LP，美国）进行荟萃分析。使用随机效应模型获得加权均数差（WMD）和 95%置信区间（CI）。使用 Begg 的漏斗图和 Egger 的回归检验评估发表偏倚。

结果

搜索策略产生了 272 篇文章，其中根据纳入/排除标准，有 18 篇文章符合条件。共有 56325 例精索静脉曲张患者和 1334694 例无精索静脉曲张患者纳入荟萃分析，以评估体尺参数对精索静脉曲张的存在和严重程度的影响。总体结果表明，精索静脉曲张的存在与身高显著相关（WMD=1.41，95%CI=1.07 至 1.74，P<0.001），与 BMI 呈负相关（WMD=-1.35，95%CI=-1.67 至-1.03，P<0.001），但与年龄（WMD=-0.93，95%CI=-2.19 至 0.33，P=0.149）或体重（WMD=0.24，95%CI=-2.24 至 2.72，P=0.850）无关。精索静脉曲张的严重程度与 BMI 的增加呈负相关，但与年龄无关。