Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, China.
Biotechnol J. 2021 Feb;16(2):e1900424. doi: 10.1002/biot.201900424. Epub 2020 Apr 22.
In recent decades, fast advancements in the fields of metal-organic frameworks (MOFs) are providing unprecedented opportunities for the development of novel functional MOFs for various biosensing applications. Exciting progress is achieved due to the combination of MOFs with various functional components, which introduces novel structures and new features to the MOFs-based biosensing applications, such as higher stability, higher sensitivity, higher flexibility, and higher specificity. This review aims to be a comprehensive summary of the most recent advances in the development of functional MOFs for various biosensing applications, placing special attention on important contributions in recent 3 years. In this review, the most recent developments in design and synthesis of functional MOFs for biosensing applications are summarized. MOFs-based biosensing applications are outlined according to the central roles of MOFs in biosensors, which include carriers of sensitive elements, enzyme-mimic elements, electrochemical signaling, optical signaling, and gas sensing. Finally, the current challenges and future development trends of functional MOFs for biosensing applications are proposed and discussed.
近几十年来，金属-有机骨架（MOFs）领域的快速发展为新型功能 MOFs 的开发提供了前所未有的机会，用于各种生物传感应用。由于 MOFs 与各种功能组件的结合，实现了令人兴奋的进展，为基于 MOFs 的生物传感应用带来了新的结构和新的特性，例如更高的稳定性、更高的灵敏度、更高的灵活性和更高的特异性。本综述旨在全面总结最近在开发各种生物传感应用的功能性 MOFs 方面的最新进展，特别关注最近 3 年的重要贡献。在本综述中，总结了用于生物传感应用的功能性 MOFs 的设计和合成的最新进展。根据 MOFs 在生物传感器中的核心作用，概述了基于 MOFs 的生物传感应用，包括敏感元件的载体、酶模拟元件、电化学信号、光学信号和气体传感。最后，提出并讨论了用于生物传感应用的功能性 MOFs 的当前挑战和未来发展趋势。
