一种弧菌噬菌体将抗阻遏作用提升到了新的水平。

A Vibriophage Takes Antirepression to the Next Level.

机构信息

Laboratory of Molecular Microbiology, Global Health Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.

出版信息

Cell Host Microbe. 2020 Apr 8;27(4):493-495. doi: 10.1016/j.chom.2020.03.019.

DOI:10.1016/j.chom.2020.03.019

PMID:32272072

Abstract

Since its isolation by Esther Lederberg, phage lambda and its repressor protein CI have contributed substantially to the advancement of molecular biology. In this issue of Cell Host & Microbe, Silpe et al. (2020) characterize the antirepressor Qtip of Vibrio phage VP882, which through CI sequestration triggers a lytic switch.

摘要

自 Esther Lederberg 分离噬菌体 λ 和其阻遏蛋白 CI 以来，它们为分子生物学的发展做出了巨大贡献。在本期《Cell Host & Microbe》中，Silpe 等人（2020）描述了噬菌 VP882 的反阻遏 Qtip，它通过 CI 隔离触发裂解开关。