Schechtman V L, Harper R M, Kluge K A, Wilson A J, Hoffman H J, Southall D P
Department of Anatomy, University of California, Los Angeles.
Sleep. 1988 Oct;11(5):413-24. doi: 10.1093/sleep/11.5.413.
Victims of the sudden infant death syndrome (SIDS) have higher overall heart rates prior to death than do control infants (1). The objective of this study was to partition these heart rate differences by state and to identify any state-dependent differences in heart rate variability and respiratory rate and variability. Twenty-two recordings of electrocardiogram (ECG) and respiration from 16 infants who subsequently died of SIDS were compared with 66 recordings of age-matched control infants. Median cardiac and respiratory rate and variability were computed for each sleep state in each recording, and one-way analysis of variance tests were performed for each variable for infants less than 1 month and for infants greater than 1 month of age. Heart rate was higher in SIDS victims less than 1 month of age than in age-matched controls during all sleep-waking states. SIDS victims greater than 1 month showed higher heart rates during rapid eye movement sleep only. Heart rate variability was also diminished during waking in victims less than 1 month, but much of this difference could be attributed to increased heart rate. These results suggest that, as a group, SIDS victims differ physiologically from control infants and that these differences may be especially prominent during particular sleep-waking states.
婴儿猝死综合征（SIDS）的受害者在死亡前的总体心率高于对照婴儿（1）。本研究的目的是按状态划分这些心率差异，并确定心率变异性、呼吸频率及变异性中任何与状态相关的差异。将16名随后死于SIDS的婴儿的22份心电图（ECG）和呼吸记录与66份年龄匹配的对照婴儿的记录进行比较。计算每份记录中每个睡眠状态下的心脏和呼吸频率及变异性中位数，并对1个月以下婴儿和1个月以上婴儿的每个变量进行单因素方差分析测试。1个月以下的SIDS受害者在所有睡眠-觉醒状态下的心率均高于年龄匹配的对照婴儿。1个月以上的SIDS受害者仅在快速眼动睡眠期间心率较高。1个月以下的受害者在清醒时心率变异性也降低，但这种差异大部分可归因于心率增加。这些结果表明，作为一个群体，SIDS受害者在生理上与对照婴儿不同，且这些差异在特定的睡眠-觉醒状态下可能尤为突出。
