Schechtman V L, Harper R M, Wilson A J, Southall D P
Brain Research Institute, UCLA School of Medicine 90024-1761.
Pediatrics. 1991 Jun;87(6):841-6.
Previous studies have shown the frequency of respiratory pauses to be altered in groups of infants at risk for the sudden infant death syndrome (SIDS). In this study, we assess the frequency of apneic pauses during quiet sleep and rapid eye movement sleep in control infants and infants who subsequently died of SIDS. Sleep states were identified in 12-hour physiological recordings of SIDS victims and matched control infants, and the number of respiratory pauses from 4 to 30 seconds in duration was computed for quiet sleep and rapid eye movement sleep. SIDS victims 40 to 65 days of age showed significantly fewer apneic pauses than did age-matched control infants across the two sleep states. Fewer short respiratory pauses accounted for most of the reduction in number of apneic events in the SIDS victims during both sleep states. During the first month of life, SIDS victims did not differ significantly from control neonates on this measure. The finding that this respiratory difference exists during the second month of life, just before the period of maximal risk for SIDS, but not earlier, may have implications for the etiology of SIDS deaths.
先前的研究表明，在有婴儿猝死综合征（SIDS）风险的婴儿群体中，呼吸暂停的频率会发生改变。在本研究中，我们评估了对照组婴儿以及随后死于SIDS的婴儿在安静睡眠和快速眼动睡眠期间呼吸暂停的频率。通过对SIDS受害者和匹配的对照婴儿进行12小时的生理记录来确定睡眠状态，并计算安静睡眠和快速眼动睡眠期间持续4至30秒的呼吸暂停次数。40至65日龄的SIDS受害者在两种睡眠状态下的呼吸暂停次数均显著少于年龄匹配的对照婴儿。在两种睡眠状态下，SIDS受害者呼吸暂停事件数量的减少主要是由于短呼吸暂停次数减少。在出生后的第一个月，SIDS受害者在这一指标上与对照新生儿没有显著差异。这一呼吸差异出现在出生后第二个月，即SIDS风险最高的时期之前，但不是更早，这一发现可能对SIDS死亡的病因学有影响。
