Peeters T L, Romanski K W, Janssens J, Vantrappen G
Dept. of Medical Research, University of Leuven, Belgium.
Scand J Gastroenterol. 1988 Sep;23(7):769-74. doi: 10.3109/00365528809090758.
The long-acting somatostatin analogue SMS 201-995, also called Sandostatin, is used in the treatment of acromegaly and peptide-secreting tumors. Little is known about its effect on gut motility, although such an effect might be expected considering the spectrum of activities of its parent molecule, somatostatin. We have studied the effect on the interdigestive motility of intravenous boluses of 0, 0.1, 0.5, 1.5, and 5.0 micrograms/kg of this analogue in 10 dogs with bipolar electrodes implanted along the entire small bowel. All doses induced, within 5 min of administration, premature phase-3 activity that was isolated to one segment, normally progressive, or simultaneous (stationary) in all channels. Only low doses induced isolated phase 3, whereas the frequency of the induction of stationary phase 3 increased with higher doses. In the next cycle of the migrating motor complex the duration of phase 1 was increased, although the duration of the whole cycle was not changed. This cycle ended with mostly ectopic phase-3 activity. During phase 2 of the following cycle ultra-rapid rushes of spiking activity progressing at a speed of 25 +/- 3 cm/sec in the upper jejunum were regularly observed. Although this pattern occurs very rarely under control conditions, it was present in 20%, 80%, and 100% of the experiments after doses of 0.5, 1.5, and 5.0 micrograms/kg, respectively. We conclude that gastrointestinal side effects observed during administration of SMS 201-995 might be related to these motility effects, which warrant further investigation. SMS 201-995 may be a tool to study the mechanism of the induction of ultra-rapid rushes and of stationary phase 3.
长效生长抑素类似物SMS 201-995，也称为善宁，用于治疗肢端肥大症和分泌肽的肿瘤。尽管考虑到其母体分子生长抑素的活性谱，可能预期它对肠道运动有影响，但目前对其影响了解甚少。我们在10只沿整个小肠植入双极电极的犬中，研究了静脉注射0、0.1、0.5、1.5和5.0微克/千克这种类似物对消化间期运动的影响。所有剂量在给药后5分钟内均诱导出早发性3期活动，该活动局限于一个节段、通常呈进行性或在所有通道中同时出现（静止）。只有低剂量诱导出孤立的3期，而静止3期的诱导频率随剂量增加而增加。在移行性运动复合波的下一个周期中，1期的持续时间增加，尽管整个周期的持续时间没有改变。这个周期以大多是异位的3期活动结束。在随后周期的2期，在上段空肠中经常观察到以25±3厘米/秒的速度进展的超快速爆发性尖峰活动。尽管这种模式在对照条件下很少出现，但在分别给予0.5、1.5和5.0微克/千克剂量后的实验中，其出现率分别为20%、80%和100%。我们得出结论，在给予SMS 201-995期间观察到的胃肠道副作用可能与这些运动影响有关，这值得进一步研究。SMS 201-995可能是研究超快速爆发和静止3期诱导机制的一种工具。
