Division of Urology, Department of Surgery, University of Utah, 50 North Medical Drive, Salt Lake City, UT 84132, USA.
IVI-RMA New Jersey, Sidney Kimmel Medical College, Thomas Jefferson University, 140 Allen Road, Basking Ridge, NJ 07920, USA.
Urol Clin North Am. 2020 May;47(2):175-183. doi: 10.1016/j.ucl.2019.12.004.
From a fertility perspective, men with azoospermia represent a challenging patient population. When no mature spermatozoa are obtained during a testicular sperm extraction, patients are often left with limited options, such as adoption or the use of donor sperm. However, it has been reported that round spermatids can be successfully injected into human oocytes and used as an alternative to mature spermatozoa. This technique is known as round spermatid injection (ROSI). Despite the limitations of ROSI and diminished clinical success rates, the use of round spermatids for fertilization may have potential as a treatment modality for men with azoospermia.
从生育的角度来看，无精子症的男性代表了一个具有挑战性的患者群体。当睾丸精子提取术未能获得成熟的精子时，患者通常只剩下有限的选择，例如收养或使用捐赠精子。然而，据报道，圆形精子细胞可以成功地注入人类卵母细胞，并作为成熟精子的替代物使用。这项技术被称为圆形精子细胞注射（ROSI）。尽管 ROSI 存在局限性和临床成功率降低，但使用圆形精子细胞进行受精可能有潜力成为无精子症男性的一种治疗方式。
