Onishi Tadanobu, Shimizu Takamasa, Akahane Manabu, Okuda Akinori, Kira Tsutomu, Omokawa Shohei, Tanaka Yasuhito
Department of Orthopedic Surgery, Nara Medical University, Kashihara, Nara, 634-8522, Japan.
Department of Public Health, Health Management and Policy, Nara Medical University School of Medicine, Kashihara, Nara, 634-8521, Japan.
J Orthop. 2020 Mar 28;21:223-227. doi: 10.1016/j.jor.2020.03.040. eCollection 2020 Sep-Oct.
No evidence exists about which biological approach is more reliable for creating non-union model. We investigated how to create a reproducible atrophic non-union model in a rat femur.
We compared three groups: simple osteotomy (group A), partial periosteum cauterization (group B), and extensive periosteum and bone marrow resection (group C).
All samples in group C demonstrated atrophic non-union in radiological, histological, and biomechanical analyses, however half of the samples in group B showed fracture healing at week 16.
Extensive resection of periosteum and bone marrow is important for a reproducible atrophic non-union model in a rat femur.
目前尚无证据表明哪种生物学方法在创建骨不连模型方面更可靠。我们研究了如何在大鼠股骨中创建可重复的萎缩性骨不连模型。
我们比较了三组:单纯截骨术(A组)、部分骨膜烧灼术(B组)和广泛骨膜及骨髓切除术(C组)。
在放射学、组织学和生物力学分析中,C组所有样本均表现为萎缩性骨不连,然而B组有一半样本在第16周时骨折愈合。
广泛切除骨膜和骨髓对于在大鼠股骨中创建可重复的萎缩性骨不连模型很重要。