Almangour Thamer A, Perry Gregory K, Alhifany Abdullah A
Department of Clinical Pharmacy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Hendrick Medical Center, 1900 Pine Street, Abilene, TX 79601, United States.
Saudi Pharm J. 2020 Apr;28(4):460-464. doi: 10.1016/j.jsps.2020.02.007. Epub 2020 Feb 17.
To assess the safety and effectiveness of dalbavancin compared to standard of care (SOC) in the treatment of osteomyelitis in adults.
A retrospective cohort study of patients with osteomyelitis due to treated with dalbavancin was conducted. Patients who received at least 2 doses of dalbavancin for the treatment of osteomyelitis between January 1, 2015 to January 31, 2018 in a single center in Texas, USA were identified and matched in 1:1 ratio with controls who received SOC. The primary efficacy outcome was the clinical success at the end of treatment. Secondary efficacy outcome was the clinical success continued for at least 3 months after the completion of the antimicrobial therapy.
During study period, 21 patients received dalbavancin for the treatment of osteomyelitis; however, only 11 patients were eligible for inclusion and matched to 11 others who received SOC. Primary outcome was achieved in all 11 patients who received dalbavancin and all those patients subsequently attained the secondary outcome. In SOC group, primary outcome occurred in 82% (9/11) of patients in which 8 out of 9 patients subsequently achieved the secondary outcome. No adverse reaction noted in either group.
Dalbavancin appears to be safe and effective for the management of osteomyelitis in adults. Further studies are needed to confirm these findings.
评估达巴万星与标准治疗（SOC）相比在治疗成人骨髓炎中的安全性和有效性。
对接受达巴万星治疗的骨髓炎患者进行回顾性队列研究。确定了2015年1月1日至2018年1月31日期间在美国得克萨斯州一个中心接受至少2剂达巴万星治疗骨髓炎的患者，并将其与接受SOC的对照组按1:1比例进行匹配。主要疗效结局是治疗结束时的临床成功。次要疗效结局是抗菌治疗完成后临床成功持续至少3个月。
在研究期间，21例患者接受达巴万星治疗骨髓炎；然而，只有11例患者符合纳入标准并与11例接受SOC的患者匹配。接受达巴万星治疗的所有11例患者均达到主要结局，且所有这些患者随后均达到次要结局。在SOC组中，82%（9/11）的患者出现主要结局，其中9例患者中的8例随后达到次要结局。两组均未观察到不良反应。
达巴万星在治疗成人骨髓炎方面似乎是安全有效的。需要进一步研究来证实这些发现。
