Fiorentini Giammaria, Sarti Donatella, Nani Roberto, Aliberti Camillo, Fiorentini Caterina, Guadagni Stefano
Onco-Hematology Department, Azienda Ospedaliera 'Ospedali Riuniti Marche Nord', 61122 Pesaro, Italy.
Department of Radiology, University Milano Bicocca, ASST Papa Giovanni XXIII, Piazza OMS - Organizzazione Mondiale della Sanità 1, 24127 Bergamo, Italy.
Hepat Oncol. 2020 Jan 21;7(1):HEP16. doi: 10.2217/hep-2019-0010.
Colorectal cancer is a worldwide public health issue, presenting an advanced stage at diagnosis in more than 20% of patients. Liver metastases are the most common metastatic sites and are not indicated for resection in 80% of cases. Unresectable colorectal cancer liver metastases that are refractory to systemic chemotherapy may benefit from transarterial chembolization with irinotecan-loaded beads (DEBIRI). Several studies show the safety and efficacy of DEBIRI for the treatment of colorectal cancer liver metastases. The development of transarterial chembolization and the introduction of new embolics have contributed to better outcomes of DEBIRI. This article reviews the current literature on DEBIRI reporting its use, efficacy in terms of tumor response and survival and side effects.
结直肠癌是一个全球性的公共卫生问题,超过20%的患者在诊断时已处于晚期。肝转移是最常见的转移部位,80%的病例不适合进行切除。对全身化疗耐药的不可切除的结直肠癌肝转移患者可能从载有伊立替康的微球经动脉化疗栓塞术(DEBIRI)中获益。多项研究表明DEBIRI治疗结直肠癌肝转移的安全性和有效性。经动脉化疗栓塞术的发展以及新栓塞剂的引入有助于DEBIRI取得更好的治疗效果。本文综述了关于DEBIRI的现有文献,报道了其应用、肿瘤反应和生存方面的疗效以及副作用。