Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
Handb Exp Pharmacol. 2022;270:3-24. doi: 10.1007/164_2020_353.
Cardiovascular disease is the leading cause of death globally The past few decades have shown that especially low- and middle-income countries have undergone rapid industrialization, urbanization, economic development and market globalization. Although these developments led to many positive changes in health outcomes and increased life expectancies, they all also caused inappropriate dietary patterns, physical inactivity and obesity. Evidence shows that a large proportion of the cardiovascular disease burden can be explained by behavioural factors such as low physical activity, unhealthy diet and smoking. Controlling these risk factors from early ages is important for maintaining cardiovascular health. Even in patients with genetic susceptibility to cardiovascular disease, risk factor modification is beneficial.Despite the tremendous advances in the medical treatment of cardiovascular risk factors to reduce overall cardiovascular risk, the modern lifestyle which has led to greater sedentary time, lower participation in active transport and time spent in leisure or purposeful physical activity, unhealthy diets and increased exposure to stress, noise and pollution have diminished the beneficial effects of contemporary medical cardiovascular prevention strategies. Therefore attenuating or eliminating these health risk behaviours and risk factors is imperative in the prevention of cardiovascular diseases.
心血管疾病是全球范围内的主要死因。过去几十年表明,特别是低收入和中等收入国家经历了快速的工业化、城市化、经济发展和市场全球化。尽管这些发展带来了许多积极的健康结果和预期寿命的增加,但它们也导致了不当的饮食模式、身体活动不足和肥胖。有证据表明,心血管疾病负担的很大一部分可以用行为因素来解释,如低身体活动、不健康的饮食和吸烟。从年轻时开始控制这些风险因素对于维持心血管健康很重要。即使在有心血管疾病遗传易感性的患者中,改变风险因素也是有益的。尽管在降低整体心血管风险方面,心血管危险因素的医学治疗取得了巨大进展,但现代生活方式导致了更多的久坐时间、减少了积极的交通方式参与度、休闲或有目的的体力活动时间增加、饮食不健康以及压力、噪音和污染的增加,这些都削弱了当代心血管预防策略的有益效果。因此,减轻或消除这些健康风险行为和风险因素对于预防心血管疾病至关重要。