Tareeva I E, Nekrasova A A, Rogov V A, Kutyrina I M, Aleksandrovskaia T N
Ter Arkh. 1988;60(8):85-9.
The effects of curantyl (dipiridamole) on the excretion of prostaglandins E2 and F2 alpha (PGF2 alpha and PGF2 alpha) and renal hemodynamics (RHD) were studied in patients with hypertensive nephritis in an acute test and during prolonged (up to 21 mos) single-agent therapy. In the acute test curantyl increased PG excretion in 15 out of 18 patients by 86.8 +/- 17.6%, mainly at the expense of PGE2 (133.2 +/- 33.1%), and renal blood flow in 11 out of 12 patients by 32.1 +/- 7.7%. During prolonged therapy curantyl also raised PGE2 excretion and improved RHD (raised renal blood flow, glomerular filtration and decreased renal vascular resistance). Besides, during prolonged single-agent therapy curantyl reduced renin plasma activity, increased circulating blood volume, insignificantly reduced BP, and possessed an antiproteinuric and antihematuric effect. It is concluded that curantyl can stimulate PG renal biosynthesis improving RHD in hypertensive nephritis that can have a beneficial effect on a course of this disease.
在急性试验以及长达21个月的单药治疗期间，研究了潘生丁对高血压性肾炎患者前列腺素E2和F2α（PGF2α）排泄及肾血流动力学（RHD）的影响。在急性试验中，18例患者中有15例潘生丁使PG排泄增加86.8±17.6%，主要是PGE2增加（133.2±33.1%），12例患者中有11例肾血流量增加32.1±7.7%。在长期治疗期间，潘生丁也使PGE2排泄增加并改善了RHD（肾血流量增加、肾小球滤过增加以及肾血管阻力降低）。此外，在长期单药治疗期间，潘生丁降低了血浆肾素活性，增加了循环血容量，轻度降低了血压，并具有抗蛋白尿和抗血尿作用。得出的结论是，潘生丁可刺激肾脏PG生物合成，改善高血压性肾炎的RHD，这可能对该疾病的病程产生有益影响。
