[线粒体DNA在脓毒症诱导的急性肺损伤/急性呼吸窘迫综合征中的作用]

[Role of mitochondrial DNA in acute lung injury/acute respiratory distress syndrome induced by sepsis].

作者信息

Zhou Liang, Tan Liping

机构信息

Department of Emergency, Children's Hospital of Chongqing Medical University; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation base of Child Development and Critical Disorders; Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China. Corresponding author: Tan Liping, Email:

出版信息

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2020 Feb;32(2):253-256. doi: 10.3760/cma.j.cn121430-20190905-00050.

DOI:10.3760/cma.j.cn121430-20190905-00050

PMID:32275019

Abstract

Sepsis is a common disease the field of critical care medicine. It is easy to be complicated by acute lung injury (ALI) or even acute respiratory distress syndrome (ARDS), which lead to high mortality. Although domestic and foreign scholars have carried out a large number of research on the pathogenesis of sepsis-related ALI/ARDS, it has not been fully elucidated so far. Recent studies have found that mitochondrial DNA (mtDNA) may play an important role in sepsis-related ALI/ARDS. This article reviews the current role of mtDNA in the pathogenesis of sepsis-related ALI/ARDS, with a view to providing new clues and evidence for the treatment of sepsis-related ALI/ARDS.

摘要

脓毒症是危重症医学领域的一种常见疾病。它很容易并发急性肺损伤（ALI）甚至急性呼吸窘迫综合征（ARDS），这会导致高死亡率。尽管国内外学者对脓毒症相关ALI/ARDS的发病机制进行了大量研究，但迄今为止尚未完全阐明。最近的研究发现，线粒体DNA（mtDNA）可能在脓毒症相关ALI/ARDS中起重要作用。本文综述了mtDNA在脓毒症相关ALI/ARDS发病机制中的当前作用，以期为脓毒症相关ALI/ARDS的治疗提供新的线索和证据。