Zhao Jun, Sheng Youyu, Dai Chunyang, Qi Sisi, Hu Ruiming, Rui Wenlong, Miao Ying, Xu Feng, Zhang Yao, Yang Qinping
Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
Department of Dermatology, Shanghai Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, China.
J Cosmet Dermatol. 2020 Nov;19(11):3115-3121. doi: 10.1111/jocd.13396. Epub 2020 Apr 10.
It has been suggested that low vitamin D levels may affect the development of hair loss.
Our aim was to evaluate the serum 25-hydroxy vitamin D [25(OH)D] status in Chinese patients with alopecia areata (AA), female pattern hair loss (FPHL), and male androgenetic alopecia (MAGA) compared with healthy individuals.
We performed a case-control study including 443 AA patients, 657 FPHL patients, 777 MAGA patients, and 2070 normal controls (1064 male and 1006 female healthy individuals) from 2015 to 2017 to analyze the correlation of serum 25(OH)D levels and hair loss in a Chinese population.
Serum 25(OH)D levels stratified by age, sex, and season were compared between patients and healthy individuals. AA patients' serum 25(OH)D levels were statistically lower than that of controls (P < .0001, α = .05). Serum 25(OH)D levels of FPHL patients (P < .0001, α = .05) and MAGA patients (P = .0005, α = .05) were also significantly lower than counterpart control subjects.
Our findings suggest an association between serum 25(OH)D levels and alopecia areata, female pattern hair loss, or male androgenetic alopecia in a Chinese population.
有研究表明，低维生素D水平可能会影响脱发的发展。
我们的目的是评估中国斑秃（AA）、女性型脱发（FPHL）和男性雄激素性脱发（MAGA）患者与健康个体相比的血清25-羟基维生素D [25(OH)D] 水平。
我们进行了一项病例对照研究，纳入了2015年至2017年的443例AA患者、657例FPHL患者、777例MAGA患者和2070例正常对照（1064名男性和1006名女性健康个体），以分析中国人群中血清25(OH)D水平与脱发之间的相关性。
比较了患者和健康个体按年龄、性别和季节分层的血清25(OH)D水平。AA患者的血清25(OH)D水平在统计学上低于对照组（P <.0001，α =.05）。FPHL患者（P <.0001，α =.05）和MAGA患者（P =.0005，α =.05）的血清25(OH)D水平也显著低于相应的对照对象。
我们的研究结果表明，中国人群中血清25(OH)D水平与斑秃、女性型脱发或男性雄激素性脱发之间存在关联。
