Long Noncoding RNA Activates Wnt/β-Catenin Signaling Pathway in Cervical Cancer Cells by Epigenetically Silencing .

Cervical cancer (CC) ranks fourth in cancers that resulted in death among women, accumulating the attention of researchers. It has been ascertained that long noncoding RNAs (lncRNAs) are crucial players in the pathological processes of a host of cancers. And, has been reported to enhance the occurrence of various cancers; however, its function in CC sustains obscure. This study explored the function of in CC and further investigates the specific molecular mechanism of in regulating CC. The levels of in CC cells were reflected by quantitative real-time polymerase chain reaction. The functions of on CC tumorigenesis were explored by colony formation, CCK-8 (Cell Counting Kit-8), EdU (ethynyl deoxyuridine), and Western blot assays. The influences of depletion on the binding of to promoter and occupancy in promoter were studied by chromatin immunoprecipitation assay. was conspicuously higher expressed in CC cells. Knockdown of was detected to ameliorate the malignant behaviors of CC cells. Importantly, the contribution of to CC development was relied on activated Wnt pathway through DDK1-mediated manner. Furthermore, it was confirmed that silencing weakened the binding of to promoter as well as the occupancy of in promoter. epigenetically silences to exacerbate the malignancy of CC via Wnt/β-catenin signaling pathway.