Laboratory of Medical Genetics, I. M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.
Laboratory of Epigenetics, Research Centre for Medical Genetics, 115522 Moscow, Russia.
Int J Mol Sci. 2022 May 22;23(10):5801. doi: 10.3390/ijms23105801.
In the last few years, more and more scientists have suggested and confirmed that epigenetic regulators are tightly connected and form a comprehensive network of regulatory pathways and feedback loops. This is particularly interesting for a better understanding of processes that occur in the development and progression of various diseases. Appearing on the preclinical stages of diseases, epigenetic aberrations may be prominent biomarkers. Being dynamic and reversible, epigenetic modifications could become targets for a novel option for therapy. Therefore, in this review, we are focusing on histone modifications and ncRNAs, their mutual regulation, role in cellular processes and potential clinical application.
在过去的几年中，越来越多的科学家提出并证实了表观遗传调控因子紧密相连，并形成了一个全面的调控途径和反馈回路网络。这对于更好地理解各种疾病的发展和进展过程特别有意义。在疾病的临床前阶段出现的表观遗传异常可能是突出的生物标志物。由于具有动态和可逆性，表观遗传修饰可能成为治疗的新选择的靶点。因此，在这篇综述中，我们专注于组蛋白修饰和 ncRNAs，它们的相互调节、在细胞过程中的作用以及潜在的临床应用。
