Chertkov I L, Gurevich O A
Biull Eksp Biol Med. 1977 Feb;83(2):206-8.
A bone marrow fragment transplanted under the kidney capsule created a focus of ectopic hemopoiesis, whose isze, measured by the number of hemopoietic cells, was proportional to the implant size. Dimensions of the focus proved to be 11/2--21/2 greater in the irradiated than in the intact recipients. Cells building up the focus of heterotopic hemopoiesis had a different radiosensitivity in the intact and irradiated recipients--their Do constituted about 160 and 350 rad, respectively. In this connection it is supposed that two cell populations of precursors took part in the creation of the focus. Their possible relations with the determined and inducible osteogenic precursor cells are discussed.
移植到肾被膜下的骨髓片段形成了一个异位造血灶,其大小(通过造血细胞数量衡量)与植入物大小成正比。结果表明,受照射受体的造血灶尺寸比未受照射受体的大1.5至2.5倍。在未受照射和受照射的受体中,构成异位造血灶的细胞具有不同的放射敏感性——它们的Do值分别约为160拉德和350拉德。由此推测,有两类前体细胞参与了造血灶的形成。文中还讨论了它们与已确定的和成骨诱导前体细胞可能存在的关系。