氨基乙酰丙酸光动力疗法联合膀胱镜检查：一种消除尖锐湿疣患者难治性人乳头瘤病毒感染的方法。
ALA-PDT combined with cystoscopy: A method to eliminate refractory HPV infection in a patient with condyloma acuminata.
作者信息
Che Qilei, Li Junpeng, Jiang Lifen, Huang Xiaowen, Zhang Mei, Liu Hui, Lang Lijuan, Zeng Kang
机构信息
Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
出版信息
Photodiagnosis Photodyn Ther. 2020 Sep;31:101763. doi: 10.1016/j.pdpdt.2020.101763. Epub 2020 Apr 7.
BACKGROUND
Condyloma acuminata is a common sexually transmitted disease for which an underlying chronic human papillomavirus (HPV) infection is an important cause of recurrence. 5-aminolaevulinic acid-mediated photodynamic therapy (ALA-PDT) has become an effective method to treat condyloma acuminata. Urinary tract condyloma acuminata are not considered common, but warts in the bladder can be detected by cystoscopy.
OBJECTIVE
To treat a urinary tract HPV infection in a 35 years old woman diagnosed with condyloma acuminata and to eliminate HPV infection.
METHOD
A total of six sessions of ALA-PDT to the cervix and seven sessions of ALA-PDT to the vagina were executed, and the patient subsequently had a cystoscope examination. The wart in the bladder was found by cystoscopy and cauterized with radiofrequency.
RESULT
Internal urethra, urethral orifice, cervical, vaginal, and vulvar HPV-DNA detection eventually all returned negative results, and there was no recurrence with two years of follow-up.
背景
尖锐湿疣是一种常见的性传播疾病，潜在的慢性人乳头瘤病毒（HPV）感染是其复发的重要原因。5-氨基乙酰丙酸介导的光动力疗法（ALA-PDT）已成为治疗尖锐湿疣的有效方法。尿道尖锐湿疣并不常见，但膀胱内的疣体可通过膀胱镜检查发现。
目的
治疗一名35岁被诊断为尖锐湿疣的女性的尿道HPV感染，并消除HPV感染。
方法
对宫颈进行了总共6次ALA-PDT治疗，对阴道进行了7次ALA-PDT治疗，随后患者接受了膀胱镜检查。通过膀胱镜检查发现膀胱内的疣体，并用射频进行烧灼。
结果
尿道内、尿道口、宫颈、阴道和外阴的HPV-DNA检测最终均呈阴性结果，随访两年无复发。
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