[F]利用氟化钠正电子发射断层显像/X线计算机体层成像（NaF PET/CT）对髂骨进行成像以评估骨转换

[F]NaF PET/CT Imaging of Iliac Bones to Assess Bone Turnover.

作者信息

Singh Shashi B, Gandhi Om H, Shrestha Bimash B, Glennan Patrick, Bahadur Anuradha Rosario, Motamedi Niloofaralsadat, Khanal Kishor, Wagle Sagar, Høilund-Carlsen Poul Flemming, Werner Thomas J, Revheim Mona-Elisabeth, Alavi Abass

机构信息

Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA, 19104, USA.

Kingston Public Hospital, North Street, Kingston 4, Jamaica.

出版信息

Mol Imaging Biol. 2025 Apr 24. doi: 10.1007/s11307-025-02003-6.

DOI:10.1007/s11307-025-02003-6

PMID:40274673

Abstract

PURPOSE

This study investigated the effects of laterality, age, gender, BMI, and physical activity level on iliac bone turnover using [F]NaF PET/CT.

PROCEDURES

Fifty-nine males and 44 females from the CAMONA study were analyzed. A region of interest (ROI) was drawn to segment the iliac bone using Hounsfield unit thresholds and morphological closing algorithm. [F]NaF SUVmean was compared between the left and right iliac bones using a paired t-test, while Pearson correlation coefficient assessed changes with age, BMI, and physical activity level.

RESULTS

[F]NaF uptake was higher in right iliac bone than left in males, females, and the combined-group. In males, SUVmean was 2.98 ± 1.63 (1.1-7.87) on left and 3.71 ± 1.49 (1.49-3.7) on right. In females, SUVmean was 2.59 ± 1.14 (0.88-6.27) on left and 3.72 ± 1.04 (2.22-6.51) on right. Combined, SUVmean was 2.81 ± 1.44 (0.88-7.87) on left and 3.71 ± 1.31 (0.89-8.07) on right. [F]NaF uptake negatively correlated with age (right: r = - 0.27, P = 0.006; left: r = - 0.22, P = 0.02), stronger in females (right: r = - 0.30, P = 0.04; left: r = - 0.31, P = 0.04) than males (right: r = - 0.26, P = 0.04; left: r = - 0.18, P = 0.18). SUVmean correlated positively with BMI in males (right: r = 0.47, P = 0.0002; left: r = 0.38, P = 0.0027), females (right: r = 0.36, P = 0.0168; left: r = 0.30, P = 0.0505), and combined-group (right: r = 0.43, P < 0.0001; left: r = 0.37, P = 0.0001). No significant correlation was found between SUVmean and physical activity in males, while in females, a negative correlation was observed on left (r = - 0.37, P = 0.0390) but not on right (r = - 0.27, P = 0.1302), and when combined, the correlation remained significant on left (r = - 0.24, P = 0.0372) but not on right (r = - 0.16, P = 0.1541).

CONCLUSIONS

[F]NaF uptake was higher in the right iliac bone and declined with age, particularly in females. The positive correlation between SUVmean and BMI; and the negative correlation between SUVmean and physical activity suggest metabolic influences on bone turnover. [F]NaF PET/CT may serve as a tool for assessing bone metabolism and turnover in asymptomatic individuals.

摘要

目的

本研究使用[F]NaF PET/CT 调查了身体侧别、年龄、性别、体重指数（BMI）和身体活动水平对髂骨骨转换的影响。

程序

分析了来自 CAMONA 研究的 59 名男性和 44 名女性。使用亨氏单位阈值和形态学闭运算算法绘制感兴趣区域（ROI）以分割髂骨。使用配对 t 检验比较左右髂骨之间的[F]NaF 标准化摄取值均值（SUVmean），同时使用 Pearson 相关系数评估其与年龄、BMI 和身体活动水平的变化。

结果

在男性、女性及合并组中，右髂骨的[F]NaF 摄取均高于左髂骨。在男性中，左侧的 SUVmean 为 2.98±1.63（1.1 - 7.87），右侧为 3.71±1.49（1.49 - 3.7）。在女性中，左侧的 SUVmean 为 2.59±1.14（0.88 - 6.27），右侧为 3.72±1.04（2.22 - 6.51）。合并后，左侧的 SUVmean 为 2.81±1.44（0.88 - 7.87），右侧为 3.71±1.31（0.89 - 8.07）。[F]NaF 摄取与年龄呈负相关（右侧：r = - 0.27，P = 0.006；左侧：r = - 0.22，P = 0.02），在女性中更强（右侧：r = - 0.30，P = 0.04；左侧：r = - 0.31，P = 0.04），而在男性中较弱（右侧：r = - 0.26，P = 0.04；左侧：r = - 0.18，P = 0.18）。SUVmean 在男性（右侧：r = 0.47，P = 0.0002；左侧：r = 0.38，P = 0.0027）、女性（右侧：r = 0.36，P = 0.0168；左侧：r = 0.30，P = 0.0505）及合并组（右侧：r = 0.43，P < 0.0001；左侧：r = 0.37，P = 0.0001）中均与 BMI 呈正相关。在男性中，未发现 SUVmean 与身体活动之间存在显著相关性，而在女性中，左侧观察到负相关（r = - 0.37，P = 0.0390），右侧未观察到（r = - 0.27，P = 0.1302），合并后，左侧相关性仍显著（r = - 0.24，P = 0.0372），右侧未观察到（r = - 0.16，P = 0.1541）。