miR-144：癌症中一个新的可能的治疗靶点和诊断/预后工具。

Student Research Committee, Birjand University of Medical Sciences, Birjand 9717853577, Iran.

Department of Immunology, Birjand University of Medical Sciences, Birjand 9717853577, Iran.

Int J Mol Sci. 2020 Apr 8;21(7):2578. doi: 10.3390/ijms21072578.

MicroRNAs (miRNAs) are small and non-coding RNAs that display aberrant expression in the tissue and plasma of cancer patients when tested in comparison to healthy individuals. In past decades, research data proposed that miRNAs could be diagnostic and prognostic biomarkers in cancer patients. It has been confirmed that miRNAs can act either as oncogenes by silencing tumor inhibitors or as tumor suppressors by targeting oncoproteins. MiR-144s are located in the chromosomal region 17q11.2, which is subject to significant damage in many types of cancers. In this review, we assess the involvement of miR-144s in several cancer types by illustrating the possible target genes that are related to each cancer, and we also briefly describe the clinical applications of miR-144s as a diagnostic and prognostic tool in cancers.

微小 RNA（miRNA）是小的非编码 RNA，与健康个体相比，在癌症患者的组织和血浆中检测到其表达异常。在过去的几十年中，研究数据表明，miRNA 可能是癌症患者的诊断和预后生物标志物。已经证实，miRNA 可以通过沉默肿瘤抑制剂作为致癌基因，也可以通过靶向癌蛋白作为肿瘤抑制因子。miR-144s 位于染色体 17q11.2 区域，该区域在许多类型的癌症中受到严重损伤。在本综述中，我们通过说明与每种癌症相关的可能靶基因，评估了 miR-144s 在几种癌症类型中的作用，我们还简要描述了 miR-144s 作为癌症诊断和预后工具的临床应用。