Department of Epidemiology and Biostatistics, School of Public Health, Texas A&M University, 212 12 Adriance Lab Road, College Station, TX 77843, USA.
Int J Environ Res Public Health. 2020 Apr 8;17(7):2561. doi: 10.3390/ijerph17072561.
In this paper, we aimed to investigate the potential impacts of a fire accident in a fertilizer warehouse on chromosomal anomalies, including Trisomy 21 (T21) and Trisomy (T18) among pregnancies in Brazos County, Texas. We conducted an observational study in Brazos County, TX, with all patients of T18 and T21 cases in the live births in Brazos County between 2005-2014. The prevalence of T18 and T21 before, during, and after the accident in Brazos County were calculated and compared. The Standardized Morbidity Ratio (SMR) was applied to compare the prevalence of T18 and T21 in Brazos County to the statewide prevalence in Texas after adjusting for maternal race and age. Compared with statewide risk, the risk of T18 during the impacted years in Brazos county was found to be significantly higher (SMR = 5.0, 95% Confidence Interval(CI): 2.19-9.89), while there was no significant difference before (SMR = 0.77, 0.13-2.54) and after the accident (SMR = 0.71, 0.12-2.36). However, the prevalence of T21 during the impacted years was not significantly different from those before or after the accident. This study conclusively suggests that this fertilizer fire may be related to the increased prevalence of T18 in Brazos County, though the findings warrant further investigation.
本研究旨在探讨德克萨斯州布拉索斯县化肥仓库火灾事故对染色体异常（包括 21 三体综合征（T21）和 18 三体综合征（T18））的潜在影响。我们在德克萨斯州布拉索斯县进行了一项观察性研究，纳入了 2005 年至 2014 年间该县所有活产儿中 T18 和 T21 病例的患者。计算并比较了布拉索斯县事故前后 T18 和 T21 的患病率。应用标准化发病比（SMR），在调整了母亲种族和年龄后，比较了布拉索斯县 T18 和 T21 的患病率与德克萨斯州全州的患病率。与全州风险相比，在受影响的布拉索斯县年份，T18 的风险明显更高（SMR = 5.0，95%置信区间（CI）：2.19-9.89），而事故前（SMR = 0.77，0.13-2.54）和事故后（SMR = 0.71，0.12-2.36）没有显著差异。然而，受影响年份的 T21 患病率与事故前或后无显著差异。本研究明确表明，这场化肥火灾可能与布拉索斯县 T18 患病率的增加有关，但这一发现需要进一步调查。
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