General Surgery, University Hospital Ayr, Ayr, UK.
BMJ Case Rep. 2020 Apr 9;13(4):e232411. doi: 10.1136/bcr-2019-232411.
Splenic rupture is a potentially life-threatening condition and an uncommon short-term complication of granulocyte-colony stimulating factor (G-CSF) administration. It may present as acute abdominal pain or suddenly precipitously worsening anaemia with haemodynamic instability that requires urgent operative intervention for survival. We present a case of an atraumatic idiopathic splenic rupture in University Hospital, Ayr in a patient who received G-CSF treatment for chemotherapy-induced (methotrexate) pancytopenia and was successfully managed by laparoscopic splenectomy.
脾破裂是一种潜在危及生命的疾病，也是粒细胞集落刺激因子（G-CSF）给药的一种罕见短期并发症。它可能表现为急性腹痛，或者突然急剧恶化的贫血伴血流动力学不稳定，需要紧急手术干预以维持生命。我们在 Ayr 大学医院报告了一例因化疗引起（甲氨蝶呤）全血细胞减少症而接受 G-CSF 治疗的患者的非创伤性特发性脾破裂病例，该患者成功地通过腹腔镜脾切除术进行了治疗。
