Becker P S, Wagle M, Matous S, Swanson R S, Pihan G, Lowry P A, Stewart F M, Heard S O
Department of Medicine, University of Massachusetts Medical Center, Worcester 01655, USA.
Biol Blood Marrow Transplant. 1997 Apr;3(1):45-9.
Granulocyte colony-stimulating factor (G-CSF) has been used to improve granulocyte count in chronic neutropenia and myelodysplasia, to minimize the incidence and duration of neutropenia during conventional chemotherapy, and to mobilize peripheral blood stem cells prior to leukapheresis for use in autologous and allogeneic marrow transplantation. The most common toxicity is bone pain, and other reactions such as inflammation at the site of injection have also occurred. In patients with chronic neutropenia, splenomegaly has been described with long-term use, and extramedullary hematopoiesis has also been reported. However, thus far, no life-threatening sequelae of these effects are found in the literature. We now describe a case of spontaneous splenic rupture four days following a six-day course of G-CSF therapy in an allogeneic donor of peripheral blood stem cells.
粒细胞集落刺激因子（G-CSF）已被用于提高慢性中性粒细胞减少症和骨髓增生异常综合征患者的粒细胞计数，减少传统化疗期间中性粒细胞减少症的发生率和持续时间，并在白细胞单采术前动员外周血干细胞，以用于自体和异基因骨髓移植。最常见的毒性是骨痛，也出现过其他反应，如注射部位炎症。在慢性中性粒细胞减少症患者中，长期使用G-CSF会出现脾肿大，也有髓外造血的报道。然而，迄今为止，文献中未发现这些影响会导致危及生命的后遗症。我们现在描述一例在外周血干细胞异体供者接受为期六天的G-CSF治疗后四天出现自发性脾破裂的病例。
