肥胖症患者高胰岛素血症时乳腺癌的进展

Tumor Progression of Breast Cancer during Hyperinsulinemic Obesity.

机构信息

Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA 30322, USA.

出版信息

Trends Mol Med. 2020 Apr;26(4):354-356. doi: 10.1016/j.molmed.2020.01.014. Epub 2020 Feb 13.

DOI:10.1016/j.molmed.2020.01.014

PMID:32277929

Abstract

Factors of metabolic syndrome including hyperinsulinemia and obesity are well known to increase the risk of cancer incidence and progression. In a recent iScience article, Ramos et al. demonstrate a novel tumor-suppressor role of the circadian transcription factor BMAL1 in triple-negative breast cancer (TNBC) specifically under conditions of hyperinsulinemia.

摘要

代谢综合征的相关因素，包括高胰岛素血症和肥胖，众所周知会增加癌症发病率和进展的风险。在最近的一篇《iScience》文章中，Ramos 等人证明了生物钟转录因子 BMAL1 在三阴性乳腺癌（TNBC）中具有一种新的肿瘤抑制作用，特别是在高胰岛素血症的情况下。