Del Bigio M R, Bruni J E
Department of Surgery (Section of Neurosurgery), Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
Acta Neuropathol. 1988;77(2):186-95. doi: 10.1007/BF00687430.
Hydrocephalus was induced in adult rabbits by injection of silicone oil into the cisterna magna. The frontal horns of the lateral ventricles enlarged to the greatest degree and reached maximum size within 3 days. Cilia and microvilli were progressively lost from the ependymal surface primarily over the corpus callosum. Stretching and flattening of ependymal cells was most pronounced over the septal area. Mitotic activity was significantly increased among the ependymal cells and subependymal astrocytes over the caudate nucleus and corpus callosum during the 2 weeks immediately following induction of hydrocephalus. Cerebrospinal fluid shunting returned the ventricles to normal size. Following shunting, however, the periventricular tissue did not resume a normal appearance. Longer durations of hydrocephalus were associated with less recovery of the periventricular tissue following shunting.
通过向成年兔的枕大池注射硅油诱导脑积水。侧脑室额角扩大程度最大，并在3天内达到最大尺寸。室管膜表面的纤毛和微绒毛主要在胼胝体上方逐渐消失。室管膜细胞的伸展和扁平化在隔区最为明显。在脑积水诱导后的2周内，尾状核和胼胝体上方的室管膜细胞和室管膜下星形胶质细胞的有丝分裂活性显著增加。脑脊液分流使脑室恢复正常大小。然而，分流后，脑室周围组织并未恢复正常外观。脑积水持续时间越长，分流后脑室周围组织的恢复越少。
