Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Biomed Pharmacother. 2020 Jul;127:110126. doi: 10.1016/j.biopha.2020.110126. Epub 2020 Apr 8.
Pancreatic cancer is a lethal disease, and new treatments need to be explored. Huaier extract is a traditional Chinese medicine that has been found to exert antitumor properties in some cancers. However, the role of Huaier extract in pancreatic cancer has not been examined. In this study, we found that the proliferation, migration, invasion and EMT (epithelial-mesenchymal transition) of pancreatic cancer cells were suppressed by treatment with Huaier extract and that apoptosis increased. We also observed that expression of β-catenin was inhibited by Huaier extract. Furthermore, an animal study showed that Huaier extract slowed tumor growth in pancreatic cancer. Our results reveal that Huaier extract suppresses pancreatic cancer by inhibiting Wnt/β-catenin pathway both in vitro and in vivo.
胰腺癌是一种致命的疾病，需要探索新的治疗方法。槐耳提取物是一种中药，已被发现对某些癌症具有抗肿瘤特性。然而，槐耳提取物在胰腺癌中的作用尚未得到检验。在这项研究中，我们发现槐耳提取物处理可抑制胰腺癌细胞的增殖、迁移、侵袭和 EMT（上皮-间充质转化），并促进细胞凋亡。我们还观察到槐耳提取物抑制β-catenin 的表达。此外，动物研究表明槐耳提取物可减缓胰腺癌肿瘤的生长。我们的研究结果表明槐耳提取物通过抑制 Wnt/β-catenin 通路在体外和体内均能抑制胰腺癌。
