Department of Chemical and Biomolecular Engineering and KI for Health Science and Technology (KIHST), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, South Korea.
Department of Chemical and Biomolecular Engineering and KI for Health Science and Technology (KIHST), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, South Korea.
Anal Chim Acta. 2020 May 8;1110:199-223. doi: 10.1016/j.aca.2020.01.057. Epub 2020 Jan 27.
Spiropyrans are a class of photochromic compounds that feature two main isoforms, a closed spiropyran (SP) and an open merocyanine (MC), which are inter-switchable with UV and visible light. The double bond containing MC isomer has several resonance forms with different optical spectra. Consequently, the overall spectral characteristic of the spiropyran solution depends on the relative contribution of each resonance form. In addition, the reversible changes of the absorbance or fluorescence spectra of MC are dictated by the environment. By utilizing these properties, spiropyran and its derivatives have been employed to monitor a variety of molecules and ions that can alter the resonance forms of MC. In this review, we provide a comprehensive discussion on a range of species that can be detected by spiropyran including metal ions, anions, acids, solvents, and even biomolecules, the major analytical detection mechanisms involved, and the novelty of such techniques. This study establishes spiropyran as a versatile platform for the detection of both organic and inorganic target molecules.
螺吡喃是一类光致变色化合物，具有两种主要的互变异构体，即闭合的螺吡喃（SP）和开环的伪轮烯（MC），它们可以通过紫外光和可见光进行互变。含双键的 MC 异构体具有几种具有不同光学光谱的共振形式。因此，螺吡喃溶液的整体光谱特性取决于每个共振形式的相对贡献。此外，MC 的吸收或荧光光谱的可逆变化取决于环境。利用这些性质，螺吡喃及其衍生物已被用于监测各种可以改变 MC 共振形式的分子和离子。在这篇综述中，我们全面讨论了可以通过螺吡喃检测到的一系列物质，包括金属离子、阴离子、酸、溶剂，甚至生物分子，涉及的主要分析检测机制，以及此类技术的新颖性。这项研究确立了螺吡喃作为检测有机和无机目标分子的多功能平台。
