Institute of Health and Biomedical Innovation, School of Optometry and Vision Science, Queensland University of Technology, Australia.
Johnson & Johnson Vision, Inc, Jacksonville, FL, USA.
Cont Lens Anterior Eye. 2020 Jun;43(3):285-297. doi: 10.1016/j.clae.2020.03.015. Epub 2020 Apr 8.
Frequent replacement contact lenses made from the etafilcon A hydrogel lens material were introduced onto the market over 30 years ago, and etafilcon A remains the most widely used hydrogel lens material today. Although the prescribing of silicone hydrogel lenses is increasing, millions of lens wearers globally have been wearing hydrogel lenses for many years and exhibit a physiologically-stable 'quiet eye', with a low profile of adverse events. Hydrogel lenses are demonstrated to maintain a low inflammatory response and infection risk profile during daily wear, which in the case of etafilcon A, may be related to its low modulus, and the naturally-protective, anti-microbial, non-denatured lysozyme absorbed into the lens from the tear fluid. Although improved corneal physiology from decreased hypoxia with silicone hydrogel lenses is well accepted, equivalent levels of corneal oxygenation are maintained during daily wear of low to medium powered hydrogel lenses, which do not impede the daily corneal de-swelling process, and do not induce clinically significant changes in ocular health. Therefore, hydrogel lenses remain an important alternative for daily wear in modern contact lens practice.
30 多年前，市场上推出了由氟硅酮 A 水凝胶镜片材料制成的频繁更换接触镜，而氟硅酮 A 仍然是当今使用最广泛的水凝胶镜片材料。尽管硅酮水凝胶镜片的处方量正在增加，但全球仍有数百万人多年来一直佩戴水凝胶镜片，表现出生理稳定的“安静眼”，不良事件发生率低。水凝胶镜片在日常佩戴时表现出低炎症反应和低感染风险，在氟硅酮 A 的情况下，这可能与其低模量以及从泪液中吸收到镜片中的天然保护性、抗微生物、非变性溶菌酶有关。虽然硅酮水凝胶镜片可改善缺氧引起的角膜生理状况已被广泛接受，但在日常佩戴低到中度功率的水凝胶镜片时，角膜仍能保持相同的氧合水平，这不会阻碍日常角膜消肿过程，也不会引起眼部健康的临床显著变化。因此，水凝胶镜片仍然是现代隐形眼镜实践中日常佩戴的重要选择。
