Ponzini Erika, Maspero Francesco, Galli Anna, Tavazzi Silvia
Materials Science Department, University of Milano Bicocca, Via R. Cozzi 55, 20125, Milan, Italy.
COMiB Research Center, University of Milano Bicocca, Via R. Cozzi 55, 20125, Milan, Italy.
Sci Rep. 2024 Apr 3;14(1):7870. doi: 10.1038/s41598-024-55937-2.
In contact lens (CL) wear, dehydration needs to be tailored to avoid dryness and related symptoms. In this view, this work aims to assess and compare the in-vitro dehydration kinetics of five CL materials, including the newly developed Kalifilcon A CL. At 36 °C and 60% relative humidity, the in-vitro dehydration kinetics of the different CLs were compared using a gravimetric method. CLs were analyzed either after a rinse of a few seconds in preservative-free saline solution or after a 24-h incubation in the same solution. A model based on the Fick diffusion equation was employed to deduce a water kinetics coefficient, providing insights into water diffusion within the polymeric matrix. The study reveals that all materials exhibit a non-Fickian dehydration behavior, with significant differences in dehydration kinetics coefficients and dehydration rate slopes. Etafilcon A and Omafilcon A, both hydrogel CLs, exhibit a similar behavior, different compared to the pattern shown by Senofilcon A and Delefilcon A, silicone-hydrogel CLs. Notably, Kalifilcon A, despite being a silicone-hydrogel, displays a hydration behavior reminiscent of hydrogel CLs.
在佩戴隐形眼镜（CL）时，需要控制脱水情况以避免干眼及相关症状。基于此，本研究旨在评估和比较五种CL材料的体外脱水动力学，其中包括新开发的Kalifilcon A隐形眼镜。在36°C和60%相对湿度条件下，采用重量法比较不同CL的体外脱水动力学。将隐形眼镜在无防腐剂的盐溶液中冲洗几秒钟后，或在相同溶液中孵育24小时后进行分析。采用基于菲克扩散方程的模型推导水动力学系数，以深入了解聚合物基质中的水扩散情况。研究表明，所有材料均表现出非菲克ian脱水行为，脱水动力学系数和脱水速率斜率存在显著差异。两种水凝胶CL材料Etafilcon A和Omafilcon A表现出相似的行为，与硅水凝胶CL材料Senofilcon A和Delefilcon A的模式不同。值得注意的是，Kalifilcon A尽管是硅水凝胶，但表现出类似于水凝胶CL的水合行为。
