Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Old Road, University of Oxford, Headington, Oxford OX3 7LD, UK.
Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Old Road, University of Oxford, Headington, Oxford OX3 7LD, UK.
Trends Cancer. 2020 Jul;6(7):538-540. doi: 10.1016/j.trecan.2020.03.010. Epub 2020 Apr 8.
The transforming growth factor beta (TGFβ) signalling pathway regulates a range of important cellular processes in a context-dependent manner. Recent discoveries have provided important insights into the regulation of the TGFβ pathway and its change from an antitumorigenic to a protumorigenic pathway. These findings may have important implications for cancer stem cell (CSC) functions and therapeutic strategies.
转化生长因子β（TGFβ）信号通路以依赖于上下文的方式调节一系列重要的细胞过程。最近的发现为 TGFβ 通路的调控及其从抗肿瘤途径向促肿瘤途径的转变提供了重要的见解。这些发现可能对癌症干细胞（CSC）功能和治疗策略具有重要意义。
