Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Education and Support for Regional Medicine, Tohoku University Hospital, Sendai, Japan.
Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Neurology, National Hospital Organization Yonezawa National Hospital, Yonezawa, Japan.
J Neuroimmunol. 2020 Jun 15;343:577236. doi: 10.1016/j.jneuroim.2020.577236. Epub 2020 Apr 7.
Predisposing factors before the onset of neuromyelitis optica spectrum disorders (NMOSD) have not been systematically evaluated by now. We investigated the detailed pre-onset history in consecutive NMOSD patients. Thirteen of the enrolled 53 NMOSD patients (24.5%) had accompanying autoimmune diseases, such as Sjögren's syndrome. History of malignancy was seen in 8 of the 53 patients (15.1%). Recent history of non-neurological clinical episodes, such as systemic allergic reaction, systemic infection, surgical operation, or traumatic injury, was seen in 23 of the 53 patients (43.4%). NMOSD patients are likely to have pre-onset history of other autoimmune diseases, malignancy, or recent non-neurological systemic conditions, which may predispose or trigger the onset of NMOSD.
目前尚未系统评估视神经脊髓炎谱系疾病（NMOSD）发病前的诱发因素。我们调查了连续 NMOSD 患者的详细发病前病史。在入组的 53 例 NMOSD 患者中，有 13 例（24.5%）伴有自身免疫性疾病，如干燥综合征。53 例患者中有 8 例（15.1%）有恶性肿瘤病史。53 例患者中有 23 例（43.4%）有近期非神经科临床发作史，如全身性过敏反应、全身感染、手术或创伤。NMOSD 患者可能有其他自身免疫性疾病、恶性肿瘤或近期非神经系统性疾病的发病前病史，这些疾病可能导致或引发 NMOSD 的发作。
