Department of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun, 130062, China.
The Second Clinical School of Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine-Zhuhai Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510120, Guangdong, China.
Clin Transl Oncol. 2020 Nov;22(11):1938-1951. doi: 10.1007/s12094-020-02348-0. Epub 2020 Apr 11.
Macrophages play an important role in the immune system as a key host defense against pathogens. Non-polarized macrophages can differentiate into pro-inflammatory classical pathway-activated macrophages or anti-inflammatory alternative pathway-activated macrophages, both of which play central roles in breast cancer growth and progression in a process called polarization of macrophages. Classical pathway-activated and alternative pathway-activated macrophages can transform into each other and their transformational properties and orientation are determined by cytokines in the tumor microenvironment. Tumor-associated macrophages display many functions, such as tissue reforming, participating in inflammation and tumor growth in breast cancer progression. Some cytokines, such as interleukins and transcriptional activators, reside in the tumor microenvironment and influence tumor-associated macrophages. Chemotherapy is a common treatment for breast cancer and macrophages play an important role in mammary tumor cell migration, cancer invasion, and angiogenesis. This review summarizes the activities of tumor-associated macrophages in the mammary tumor, chemotherapeutic processes and some potential strategies for breast cancer therapy.
巨噬细胞在免疫系统中发挥着重要作用，是宿主抵抗病原体的关键。非极化巨噬细胞可以分化为促炎经典途径激活的巨噬细胞或抗炎替代途径激活的巨噬细胞，这两种巨噬细胞在乳腺癌生长和进展过程中都起着核心作用，这一过程称为巨噬细胞极化。经典途径激活的和替代途径激活的巨噬细胞可以相互转化，它们的转化特性和方向取决于肿瘤微环境中的细胞因子。肿瘤相关巨噬细胞具有许多功能，例如组织重塑，参与乳腺癌进展中的炎症和肿瘤生长。一些细胞因子，如白细胞介素和转录激活因子，存在于肿瘤微环境中，影响肿瘤相关巨噬细胞。化疗是乳腺癌的常见治疗方法，而巨噬细胞在乳腺肿瘤细胞迁移、癌症浸润和血管生成中起着重要作用。本文综述了肿瘤相关巨噬细胞在乳腺肿瘤、化疗过程中的作用以及一些乳腺癌治疗的潜在策略。
