College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, China.
Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Shenyang Agricultural University, Shenyang, 110866, China.
Cell Commun Signal. 2023 Aug 4;21(1):197. doi: 10.1186/s12964-023-01208-y.
Macrophages are immune cells with high plasticity that are widely distributed in all tissues and organs of the body. Under the influence of the immune microenvironment of breast tumors, macrophages differentiate into various germline lineages. They exert pro-tumor or tumor-suppressive effects by secreting various cytokines. Pyroptosis is mediated by Gasdermin family proteins, which form holes in cell membranes and cause a violent inflammatory response and cell death. This is an important way for the body to fight off infections. Tumor cell pyroptosis can activate anti-tumor immunity and inhibit tumor growth. At the same time, it releases inflammatory mediators and recruits tumor-associated macrophages (TAMs) for accumulation. Macrophages act as "mediators" of cytokine interactions and indirectly influence the pyroptosis pathway. This paper describes the mechanism of action on the part of TAM in affecting the pyroptosis process of breast tumor cells, as well as its key role in the tumor microenvironment. Additionally, it provides the basis for in-depth research on how to use immune cells to affect breast tumors and guide anti-tumor trends, with important implications for the prevention and treatment of breast tumors. Video Abstract.
巨噬细胞是具有高度可塑性的免疫细胞，广泛分布于全身各组织器官。在乳腺肿瘤的免疫微环境影响下，巨噬细胞分化为各种胚系谱系。它们通过分泌各种细胞因子发挥促肿瘤或抑肿瘤作用。细胞焦亡是由 Gasdermin 家族蛋白介导的，这些蛋白在细胞膜上形成孔，导致剧烈的炎症反应和细胞死亡。这是身体抵御感染的重要方式。肿瘤细胞焦亡可激活抗肿瘤免疫，抑制肿瘤生长。同时，它释放炎症介质并募集肿瘤相关巨噬细胞（TAMs）聚集。巨噬细胞作为细胞因子相互作用的“介质”，间接影响细胞焦亡途径。本文描述了 TAM 在影响乳腺肿瘤细胞焦亡过程中的作用机制及其在肿瘤微环境中的关键作用。此外，它为深入研究如何利用免疫细胞影响乳腺肿瘤和指导抗肿瘤趋势提供了依据，对乳腺肿瘤的防治具有重要意义。视频摘要。
